Potential Role of TRPV4 in Stretch-Induced Ghrelin Secretion and Obesity To investigate the bioactivity of TRPV4, MGN3-1 cells were treated with TRPV4 agonists and antagonists, and changes in intracellular Ca2+ concentration ... S Hayakawa,T Tanaka,R Ogawa,... - 《International Journal of End...
Consequently, modulation of TRPV4 function with small molecules is of interest to those working in the biomedical and drug discovery communities. Herein, we review the main chemotypes that have been disclosed as either TRPV4 agonists or antagonists. Where applicable, we also highlight the ...
TRPV4 agonists and antagonists. Curr Top Med Chem 2011; 11: 2216–2226. 22 Cao Q, Yu J, Dhanasekaran SM, Kim JH, Mani RS, Tomlins SA et al. Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene 2008; 27: 7274–7284. 23 Come C, Arnoux V, Bibeau F,...
TRPV4 agonists and antagonists. Curr Top Med Chem 2011; 11: 2216–2226. Article CAS Google Scholar Cao Q, Yu J, Dhanasekaran SM, Kim JH, Mani RS, Tomlins SA et al. Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene 2008; 27: 7274–7284. Article CAS...
TRPC4 knockdown suppresses epidermal growth factor-induced store-operated channel activation and growth in human corneal epithelial cells J. Biol. Chem. (2005) B.G.Lawhornet al. Recent advances in TRPV4 agonists and antagonists Bioorg. Med. Chem. Lett. ...
agonists or antagonists was conducted as well, and we found that the TRPV4 agonist GSK enhanced TRPV4 function and rescued the motility inhibited by knockdown. In recent years, the roles of TRPV4 in cell proliferation, differentiation, and migration had been extensively studied. Its abnormal expre...
Programmed cell death is a major life activity of both normal development and disease. Necroptosis is early recognized as a caspase-independent form of pro
ATP and UDP constrict rat intrapulmonary arteries, but which receptors mediate these actions is unclear. Here, we used selective agonists and antagonists, ... Callum,Mitchell,Nawazish-i-Husain,... - 《Journal of Pharmacology & Experimental Therapeutics》 被引量: 9发表: 2012年 Leukotriene D_4-In...
The TRPA1 agonists allyl isothiocyanate and cinnamaldehyde and the TRPV4 agonist GSK1016790A caused a concentration-dependent increase in intracellular Ca(2+) concentration that was inhibited by the selective antagonists HC030031, AP18, and HC067047, respectively. In contrast, exposure to the TRPV...
Recent advances in TRPV4 agonists and antagonists 2020, Bioorganic and Medicinal Chemistry Letters Citation Excerpt : The methoxy-bearing analog 17 improved activity by 10-fold, prompting additional efforts that led to substituted piperazines such as 18 with exquisite potency. Compound 18 displayed good...