intoeightgroups:normalgroup,shamgroup,model1group,model2group,tuina1group,tuina2group,tuina1+transientreceptorpotentialvanilloid⁃1 (TRPV1)antagonistgroup,andtuina2+transientreceptorpotentialankyrin1(TRPA1)antagonistgroup.Themodel,tuina,andtuina+antagonistgroupswereestablishedwithminorCCImodels.Thetuinaand ...
TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory neurons involved in pain sensation and also at a number of other neuronal and non-neuronal sites in the mammalian body. Functionally, TRPV1 acts as a sensor for noxious heat (greater than ~42 °C). It can...
Lipoic-Based TRPA1/TRPV1 Antagonist to Treat Orofacial Pain Francesconi O, Richichi B, la Marca G, Ghelardini C, Moncelli MR, Nativi C (2015) Lipoic- based TRPA1/TRPV1 antagonist to treat orofacial pain. ... Roberta,Gualdani,Stefania,... - 《Acs Chemical Neuroscience》 被引量: 7...
TRPV1 antagonists, capsazepine and SB-366791, attenuated capsaicin-induced nociceptive reaction in a concentration-dependent manner. At 8 μg/20 μl, this effect was 51% ( P <0.001) for capsazepine and 37% ( P <0.05) for SB-366791. A TRPA1 antagonist, A-967079, reduced pain reaction ...
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis and attenuate OA progression have been scarce
(Story et al.,2003; Meseguer et al.,2014; Trevisani et al.,2007; Thorne et al.,1991; Silva et al.,2011). In addition, a specific TRPA1 antagonist attenuated the capsaicin (a TRPV1 agonist)-evoked increase of cutaneous blood flow adjacent to an injury site in the plantar skin of ...
At day 3, visceromotor responses were assessed before and after treatment with a TRPV1 (BCTC) or TRPA1 (TCS-5861528) receptor antagonist either alone or in combination and either after intraperitoneal or intrathecal administration. Endoscopy, microscopy and myeloperoxidase activity indicated severe ...
Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus Migraine is a debilitating headache disorder which affects approximately 12% of the general population and is the cause of significant loss of productivity... ML Sixt,K Messlinger,MJM Fischer - 《Bra...
A TRPA1 antagonist, A-967079, reduced pain reaction by 48% (P<0.05) in the AITC test and by 54% (P<0.001) in the early phase of the formalin test. The test compounds had no influence on the late phase of the formalin test. In paclitaxel-treated mice, they did not attenuate heat ...
However, the TRPA1 antagonist A967079 (10−6 M) blocked the inhibitory effects of AEA on TNF-induced IL-6 (Fig. 3a) and IL-8 (Fig. 3c) but not on MMP-3 production (Fig. 3e) in RASF. The effect of AEA together with A967079 on IL-6 and IL-8 production were inhibited when ...