In fetal mice administration of LPS altered lung development by impairing alveolarization leading to pathological changes resembling BPD, while these changes did not occur in toll-like receptor 4 (TLR-4) knock-out mice. In adult mice with influenza, treatment with a TLR4 antagonist protected the ...
The Toll-like receptor 4 (TLR4) signaling pathway is one of the most common inflammation-related pathways, and it has been demonstrated that TLR4 is highly expressed in adhesive tissues; however, the function of TLR4 in adhesion formation has not yet been studied. In the present study, the ...
Toll-like receptor 4 (TLR4) signaling contributes to inflammatory cardiovascular and renal diseases, but its role in Aldo-induced hypertension and renal damage is not clear. In the current study, rats were treated with Aldo-salt combined with TAK-242 (a TLR4 signaling antagonist) for 4 weeks....
Because inflammation in osteoarthritis (OA) is related to the Toll-like receptor 4 (TLR4) signaling cascades, TLR4 is a reasonable target for developing therapeutics for OA. Thus, we investigated whether TAP2, a peptide antagonist of TLR4, reduces the monoiodoacetate (MIA)-induced arthritic pain...
Bagheri B, Sohrabi B, Movassaghpour AA, Mashayekhi S, Garjani A, Shokri Met al. Hydrocortisone reduces Toll-like receptor 4 expression on peripheral CD14+ monocytes in patients undergoing percutaneous coronary intervention.Iran Biomed J2014;18: 76–81. ...
TLR4 antagonistToll‐like receptor 4Every year, 15 million pregnancies end prematurely, resulting in more than 1 million infant deaths and long‐term health consequences for many children. The physiological processes of labour and birth involve essential roles for immune cells and pro‐inflammatory ...
like receptor 4 (TLR4), a key receptor of innate immunity. Antagonists of HMGB1 and TLR4 retard seizure precipitation and decrease acute and chronic seizure recurrence. TLR4-defective C3H/HeJ mice are resistant to kainate-induced seizures. The proconvulsant effects of HMGB1, like those of ...
Bagheri B, Sohrabi B, Movassaghpour AA, Mashayekhi S, Garjani A, Shokri Met al. Hydrocortisone reduces Toll-like receptor 4 expression on peripheral CD14+ monocytes in patients undergoing percutaneous coronary intervention.Iran Biomed J2014;18: 76–81. ...
et al. A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G1167–G1179 (2009). Article CAS PubMed PubMed Central Google Scholar Fort, M. M. et al. A synthetic TLR4 ...
agonist in pharmacy Application of sparstolenin B as TLR2 (Toll-like receptor 2)/TLR4 (Toll-like receptor 4) antagonist in pharmacyApplication of sparstolenin B as TLR2 (Toll-like receptor 2)/TLR4 (Toll-like receptor 4) antagonist in pharmacyThe invention relates to new application of spar...