such as TREM2 and CD36 are well-documented receptors involved in the phagocytic function of microglia [34]. We therefore analyzed the expression of these receptors following CAP treatment. While there was no detectable change
PPARs are ligand-activated nuclear receptors that are involved in the transcriptional regulation of energy balance and inflammation. Nutrients such as fatty acids direct cellular biology by inducing specific transcriptional responses in the nucleus. PPARs are involved in a mechanism through which nutrient...
Skeletal muscle and nuclear hormone Cell Research | Vol 22 No 3 | March 2012 receptors: implications for cardiovascular and metabolic dis- ease. Int J Biochem Cell Biol 2005; 37:2047-2063. 3 Wang YX, Zhang CL, Yu RT, et al. Regulation of muscle fiber type and running endurance by PPAR...
Resiniferatoxin-induced loss of vanilloid receptors is reversible in the urinary bladder but not in the spinal cord of the rat. Neurosci Lett. 1993;162(1–2):197–200 (1993/11/12). CAS PubMed Google Scholar Zhang N, Zhang P, Zhang X, Yang Y. The efficacy of resiniferatoxin in ...
Application of 100 nM MLA and 100 nM DHBE to block a7 and a4b2 receptors, respectively52,55, did not block rescue of LTP in TRPV1 knockouts by nicotine (Fig. 9j)—indicating that rescue was indeed mediated specifically via a2 receptors in OLM neurons. To confirm the role of a2 ...
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice Pain (2005) T.Christophet al. Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice ...
Xu et al. identified that CAP could directly activate TRPV1 receptors in BCPAP cells, consequently suppress epithelial-mesenchymal transition and ultimately inhibit cell adhesion, migration and invasion (Xu et al., 2018). There are some researches reported that, in different osteosarcoma cell lines ...
(calcium channel, voltage-dependent, beta 3 subunit) and NMDA receptors or cytoplasmic Ca2+is also elevated, resulting in a large amount of Ca2+introduced through the TRP channel, including the TRPV1 channel, and triggering the biochemical cascade and leading to acute neuronal cell death as a ...
bypassing the TRPV1-mediated excitatory innervation defects. Most highly nicotine-sensitive nicotinic acetylcholine receptors contain the β2-subunit (CHRNB2). We therefore first examined the localization of TRPV1 and CHRNB2 in OLM neurons. We used a knock-in mouse strain in which all β2-subuni...
2 Following pathogen recognition through pattern recognition receptors (PRRs), DCs upregulate costimulatory molecules and major histocompatibility complex molecule class II (MHC II) and produce cytokines that control differentiation of naive CD4+ T cells into effector lineages. The pathogenic role of DCs ...