TRPV1 activation promotes lipolysis both in mesenteric adipose tissue and 3T3-L1 preadipocytes. A. The weights of mesenteric, perirenal and testicular adipose tissues from WT and TRPV1−/− mice fed a normal diet (ND), a high-fat diet (HD), or a high-fat plus capsaicin diet (HC)...
Since TRPV1 deletion had a detrimental outcome in CPZ-induced demyelination, we next examined whether an enforced gain-of-function of TRPV1 would have a beneficial effect on demyelination. We selected capsaicin, an agonist of TRPV1, to activate TRPV1 in these experiments. WT mice were intrap...
TRPV1 activation increased the expression of genes involved in fatty acid oxidation and mitochondrial res- piration, promoted mitochondrial biogenesis, increased oxidative fibers, enhanced exercise endurance and prevented high-fat diet-induced metabolic disorders. Importantly, these effects of capsaicin were...
To further test if functional TRPV1 is present in the hippocampus, we examined calcium responses of hippocampal neurons to capsaicin, which specifically activates the TRPV1 channel. TRPV1 is permeable to cations including Ca2+1. Monitoring Ca2+influx upon TRPV1 activation therefore allows us to ...
ApoE4 + PHF microglia after capsaicin treatment (Fig.3j). A low level of ER Ca2+triggers the transcriptional activation of SREBP2, a main transcriptional regulator of cholesterol metabolism and homeostasis [36,37]. Consistent with that, the enhanced capacity of ER Ca2+store after capsaicin...
obesity.We investigated the effect of dietary supplementation of capsaicin (CAP) (TRPV1 agonist) on the expression of metabolically important thermogenic proteins in BAT of wild-type and TRPV1mice that received either a normal chow or high-fat (卤CAP; TRPV1 activator) diet by immunoblotting....
To further test if functional TRPV1 is present in the hippocampus, we examined calcium responses of hippocampal neurons to capsaicin, which specifically activates the TRPV1 channel. TRPV1 is permeable to cations including Ca2 þ 1. Monitoring Ca2 þ influx upon TRPV1 activation therefore ...
Atherosclerosis is characterized by the accumulation of lipids within the arterial wall. Although activation of TRPV1 cation channels by capsaicin may reduce lipid storage and the formation of atherosclerotic lesions, a clinical use for capsaicin has bee
TRPV1 activation increased the expression of genes involved in fatty acid oxidation and mitochondrial respiration, promoted mitochondrial biogenesis, increased oxidative fibers, enhanced exercise endurance and prevented high-fat diet-induced metabolic disorders. Importantly, these effects of capsaicin were ...
We have recently shown that the activation of the transient receptor potential vanilloid subfamily 1 (TRPV1) protein by capsaicin (CAP; a TRPV1 agonist) counters high-fat diet (HFD; 60% of calories from fat)-induced obesity without decreasing energy intake [13,14] in mice housed at ambient...