Sensitivity testing in irritable bowel syndrome with rectal capsaicin stimulations: role of TRPV1 upregulation and sensitization in visceral hypersensitivity? Am. J. Gastroenterol. 109, 99–109 (2014). Article PubMed Google Scholar Valdez-Morales, E. E. et al. Sensitization of peripheral sensory...
Spiciness or (false) heat --Substances such as ethanol and capsaicin cause a burning sensation by inducing a trigeminal nerve reaction together with normal taste reception. The heat is caused by the food activating a nerve cell ion channel called TRP-V1, which is also activated by hot temperat...
VQOL VQP VQPF VQPRD VQQ VQR VQRC VQRP VQS VQSP VQSS VQSTOL VQT VQTS VR VR&E VR(C) VR-HS VR-IBIC VR-IPT VR-MMSC VR/AR VR/HE VR/SPC VR1 VR2 VR3 VR4 VR5 VR6 VRA VRAA VRAB VRABE VRAC VRACS VRAD VRAE VRAEM
Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut. 2008;57:923-929. [PubMed] [Cited in This Article: 2] 94. Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, Pasquinelli G...
Capsaicin is a natural product found in chili peppers, and is a special ligand of transient receptor potential vanil- loid 1 (TRPV1). When capsaicin binds to TRPV1 receptors, calcium influx occurs on heat-receptor membranes and leads to desensitization, and in the long...
Baskilab has found that high-fat-diet obesity and dietary capsaicin—0.01 percent of capsaicin in the total high fat diet—prevented high-fat-diet-induced weight gain in trials with wild type mice, but not in mice that genetically lacked TRPV1. ...
in models of ASA or stress-induced gastric ulcer was decreased by the pretreatment with capsaicin (50 µg/kg, p.o.) an antagonist of the TRPV1. According to studies by Aizawa et al. 2001 [50], NG-nitro-L-arginine methyl ester (L-NAME), inhibitor of nitric oxide synthase (NOS),...
These observations led us to reason that a potentially effective therapy for toxin A-induced colitis might be a local defunctionalization of TRPV1 by a TRPV1 excitotoxic drug such as capsaicin or RTX. Local rather than systemic TRPV1 defunctionalization is an important goal because whole body...
Capsaicin or chili pepper: “Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel‐dependent mechanisms” (2016); Green tea: “A polyphenolic extract from green tea leaves activates fat browning in high-fat-diet-induced obese mice” (2017); ...
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