为了揭开偏头痛的神秘面纱,相关研究人员在《Journal of Headache and Pain》期刊上发表了题为 “Sex-dependent roles of TRPM3 channels in migraine pathophysiology: implications for translational therapies” 的论文。研究发现,瞬时受体电位通道 Melastatin 3(TRPM3)通道可能是解开偏头痛谜团的关键钥匙,它在偏头痛的...
在这样的背景下,研究人员在《Journal of Headache and Pain》期刊上发表了一篇名为 “Sex-dependent roles of TRPM3 channels in migraine pathophysiology: implications for translational therapies” 的论文。他们发现,TRPM3 通道的功能与偏头痛的发病机制密切相关,尤其是在解释偏头痛的性别差异方面有着重要作用。这一...
Moreover, intraperitoneal injection of a TRPM3 antagonist, isosakuranetin, effectively reduced the oxaliplatin-induced pain behavior in response to cold and mechanical stimulation in mice with an acute form of oxaliplatin-induced peripheral neuropathy. In summary, TRPM3 represents a potential new ...
temperature, pressure, and pain [17,18,19]. Consequently, TRP channel dysfunction has been associated with a variety of inherited and acquired diseases in humans [20,21,
(TRP) superfamily of non-selective cation channels serve as polymodal cellular sensors that participate in diverse physiological processes across the animal kingdom including the perception of light, temperature, pressure, and pain. TRPM3 belongs to the melastatin sub-family of TRP channels and has ...
2n), induced by complete Freund’s adjuvant (CFA), which was used to induce inflammatory pain. Therefore, ATF4 selectively regulates heat nociception. TRPM3 regulates heat transduction and is especially critical for the development of heat nociception10,21. We tested the effects of ATF4 siRNA on...
Keywords:G protein-coupled receptor (GPCR) intracellular signaling and heat nociceptioninflammatory mediators and pain;membrane protein trafficking;mouse and human dorsal root ganglion (DRG) neuron;transient receptor potential (TRP) channel melastatin 3 (TRPM3);translational medicine ...
Holding Company Ltd., along with CD3 and LICR at KU Leuven, announced that they have entered into an exclusive global license and research agreement to develop and commercialize first-in-class TRPM3 antagonists to address...
Within this context, it has been reported that TRPM3 channels exhibit higher spiking activity to induce pain in female meninges compared to males, indicating a pivotal role in the mechanisms underlying sex differences in migraine pathophysiology (Krivoshein et al., 2022). Moreover, TRPM8 has ...
Fig. 1. Pain and itch behavior induced by TRPM3 agonist and capsaicin in the mouse cheek model Trpm3+/+ and Trpm3−/− mice were injected in the cheek with the agonists indicated in the figure. (A) Number of wipes, (B) bouts of scratches, and (C) total time of scratching as ...