This exchange is enabled and facilitated by a variety of highly specialised types of trophoblasts that in the mouse include syncytiotrophoblast (SynT-I and SynT-II), spongiotrophoblast (SpT) and a range of trophoblast giant cells (TGCs) among others1. They all arise from the trophectoderm, ...
The invention discloses an application of p110 delta and an antibody of the p110 delta in specifically marking an early trophoblast giant cell (Parietal TGC, pTGC). The p110 delta is a segment of p110 delta; an amino acid sequence of the segment is as described as SEQIDNO.1. According...
lamellipodia, migration, apoptosis, cell cycle progression, gene transcription and cell differentiation (Thomas & Brugge, 1997). Furthermore, many SFK members are implicated in the differentiation of different cell types. Fyn and Lck play major and different roles in T cell differentiation...
In addition, increased apoptosis in the spongiotrophoblast layer and parietal trophoblast giant cells was consistent with the accumulation of SQSTM1, a marker of autophagy inhibition, in cKO placentas, suggesting that autophagy inhibition also mediates cell death in murine trophoblasts. Regarding human...
Precocious overexpression of LATS1 resulting in a substantial decrease in the giant cell marker Prl2c2, inhibition of endoreduplication by reducing ploidy, disintegrated actin filaments as well as nuclear size reaffirms its function in trophoblast cells. ...
S100P has been shown to be a marker for carcinogenesis where its expression in solid tumours correlates with metastasis and a poor patient prognosis. This protein’s role in any physiological process is, however, unknown. Here we first show that S100P is
Although putative horse embryonic stem (ES)-like cell lines have been obtained recently from in vivo-derived embryos, it is currently not known whether it is possible to obtain ES cell (ESC) lines from somatic cell nuclear transfer (SCNT) and parthenogenetic (PA) embryos. Our aim is to esta...
Plf—marker of spiral artery-, canal-, channel-, and parietal-trophoblast giant cells (TGCs); Ctsq—marker of sinusoidal-trophoblast giant cells (S-TGC); Pcdh12—marker of glycogen trophoblast cells. Black asterisks—channel; green asterisks—lacunae lumen; black arrowheads—maternal red blood ...
D Dot plot depicts the expression of canonical angiogenesis related factors and receptors in each cell type, as revealed in the single-cell RNA sequencing (scRNA-seq) data. The color of each dot indicates the expression level of the marker gene, and the size of the dot reflects the ...
Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway. Mol Endocrinol 2008; 22: 1673–1681. 38. Suman P, Shembekar N, Gupta SK. Leukemia inhibitory factor increases ...