Trop2 is a transmembrane glycoprotein proposed as a potential therapeutic target for BC; Trop2 structure has not been clearly determined yet and its function is tissue and cell type dependent; Recently, a novel antibody-drug conjugate against Trop2 (Sacituzumab Govitecan) has been approved for ...
Trop-2全称为人滋养细胞表面抗原2(Trophoblast Cell-Surface Antigen 2 ),其实Trop-2在一众靶点之中算得上是“老面孔”了,1990年前后就被科研人员成功分离。 而后,科学家们发现,Trop-2主要有两种功能:首先,它作为一种跨膜糖蛋白,参与细胞粘附。除此之外,它还能通过促进钙从内质网流出,使细胞增殖通路磷酸化,参与...
Although first described almost 40 years ago as a cell surface marker of trophoblast cells [7], TROP-2 (trophoblast cell-surface antigen 2) was rediscovered in ensuing years as tumor-associated calcium signal transducer 2 (TACSTD2), membrane component chromosome 1 surface marker 1 (M1S1), gas...
targeting trophoblast cell surface antigen-2 (TROP-2) in patients with primary penile squamous cell carcinoma (PSCC), patients with recurrence (REC cohort), and patient-matched distant metastases (MET cohort), and to assess the potential use of TROP-2 as a predictive non-invasive biomarker in...
【我的口译关键词:Trop-2】Trophoblast cell surface antigen-2 (Trop-2) is a widely expressed glycoprotein on a variety of different tumours. Trop-2 is considered as a marker of germ cells and is associated with regenerative ability in several tissues. Some studies demonstrated both oncogenic and...
TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer Michela Cortesi, Michele Zanoni, Roberta Maltoni, Sara Ravaioli, Maria Maddalena Tumedei, Francesca Pirini & show all Pages 593-602 | Received 17 Mar 2022, Accepted 11 Aug 2022, Published online: 19 Aug ...
Trophoblast cell surface antigen 2 (TROP2) is the target of sacituzumab govitecan (SG), an antibody-drug conjugate that was recently approved for previously treated triple negative breast cancer and urothelial carcinomas. To comprehensively determine TROP2 expression in normal and neoplastic tissues,...
Global TROP2 (Trophoblast Cell-surface Antigen 2) Targeted Cancer Therapy Market- (By Application (Breast Cancer, Prostate Cancer, Lung Cancer, Colorectal Cancer, Pancreatic Cancer, and Others)), By Region, Trends, Industry Competition Analysis, Revenue and F...
Trophoblast cell-surface antigen 2 (TROP2) is related to tumor proliferation enhancement and poor prognosis. An antibody targeting TROP2 was developed to treat metastatic triple-negative breast cancer (TNBC) which has a limited treatment modality. To characterize the TROP2 expressing tumors in TNBC,...
Trophoblast cell surface antigen 2 (Trop-2) belongs to the family of tumor-associated calcium signal transducer ( TACSTD ) and is required for the stability of claudin-7 and claudin-1, which are often dysregulated or lost in carcinogenesis. Here, we investigated the effects of Trop-2 ...