Nucleic Acids Research, 2015 1doi: 10.1093/nar/gkv199Trade-offs between tRNA abundance and mRNAsecondary structure support smoothing of translationelongation rateThomas E. Gorochowski 1,* , Zoya Ignatova 2,3 , Roel A.L. Bovenberg 1 and JohannesA. Roubos 11 DSM Biotechnology Center, P.O. ...
Recently, the methyltransferase METTL8, thought of as a mRNA modifier, is identified to be mitochondrial matrix-associated for installing m3C32 in mt-tRNAs, as m3C modification in mt-tRNAs, but not in cytoplasmic tRNAs, is diminished by METTL8 knockout (Kleiber et al.2022). METTL8 has mult...
(YB-1 or YBX1) is required for SG assembly.bTranslational activation. LeuCAG 3′tsRNA binds to RPS28 mRNA and alters the secondary structure, leading to the activation of translation.cTranslational activation inTrypanosoma brucei(T. brucei). The production of Thr 3′tRNA half is promoted ...
Further evidences for the poly-tRNA theory on the origin of mRNA and genetic codes: Poly-tRNA structure in the bacilluis subtilis rrnB operon is also a relic of an early peptide-synthesizing RNA moleculeAn of the paper "Further Evidences for the Poly-tRNA Theory on the Origin of mRNA and ...
aminoacyl-tRNA has been synthesized, the amino acid part makes no contribution to accurate translation of the mRNA. Instead, this is achieved by the codon recognition through base pairing viaanticodonof aminoacyl-tRNA. Therefore, it is important that the right amino acid be matched with its ...
Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions. Nat. Struct. Mol. Biol. 26, 1094–1105 (2019). Article CAS PubMed PubMed Central Google Scholar Ohmori, S. et al. RNA Aptamers for a tRNA-binding protein from aeropyrum pernix with homologous counterparts ...
Further evidences for the poly-tRNA theory on the origin of mRNA and genetic codes: Poly-tRNA structure in thebacilluis subtilis rrnB operon is also a reli... Koji,Ohnishi - 《Origins of Life & Evolution of the Biosphere》 被引量: 0发表: 1996年 THE SYNTHESIS OF TEICHOIC ACIDS. II. ...
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Muta...
(Fig.3d, Additional file1: Figure S3h), suggesting a potentially coordinated decrease in the dynamic range for both tRNA supply and mRNA demand. Thus, we speculate that cell-type-specific tRNA levels may be adjusted in a manner that complements the dynamic range of codon usage rather than ...
Reading of the genetic code takes place in the ribosome one amino acid at a time via base pairing between the mRNA codon and the tRNA anticodon; in this way, each amino acid is brought to the ribosome and polymerized into the growing polypeptide chain in precisely the order specified within...