5’-tRF-GlyGCC在结直肠癌患者血浆中上调,并随着结直肠癌的进展和转移而升高。 收集16对肿瘤组织和血浆样本,验证5’-tRF-GlyGCC在CRC组织和相同患者血浆中的表达是否存在相关性。结果显示5’-tRF-GlyGCC在血浆中的表达与配对CRC组织中的表达显著相关(图2i)。提示血浆中5’-tRF-GlyGCC水平较高的患者在结直肠癌...
Blood cells co-cultured with CRC cells or mice xenografted with CRC tumors show increased levels of 5′-tRF-GlyGCC. In addition, we find that the increased expression of 5′-tRF-GlyGCC is dependent on the upregulation of AlkB homolog 3 (ALKBH3), a tRNA demethylase which can promote ...
i-tRF-GlyGCC expression maintained its prognostic value independently of other established prognostic factors, as shown by the multivariate Cox regression analysis. Additionally, survival analysis after TNM stage stratification revealed that higher i-tRF-GlyGCC levels were linked...
Circulatory exosomal tRF-Glu-CTC-005 and tRF-Gly-GCC-002 serve as predictive factors of successful microdissection testicular sperm extraction in patients with nonobstructive azoospermia - ScienceDirectQiang Zhang Ph.D. aZhao Liu M.S. fXiaoxiao Han M.D. g...
Moreover, PARP9 expression was decreased in tRF-Gly-GCC antagomir treated group compared to control group.#Conclusions:In conclusion, tRF-Gly-GCC aggravated ischemic injury, suggesting that it may serve as a potential therapeutic target for cerebral ischemia.Wen Dong...
tRF-1:30-Gly-GCC-2 may be a novel molecular target for improving the development of atretic follicles in ovarian dysfunction. In conclusion, our study provides a new perspective on the pathogenesis of granulosa cell dysfunction and follicular atresia....
biomedicines Article High Intratumoral i-tRF-GlyGCC Expression Predicts Short-Term Relapse and Poor Overall Survival of Colorectal Cancer Patients, Independent of the TNM Stage Spyridon Christodoulou 1, Katerina Katsaraki 2 , Panteleimon Vassiliu 1, Nikolaos Danias 1, Nikolaos Michalopoulos 1, ...
Interestingly, i-tRF-GlyGCC integration in multivariate strategies benefits prognostication and achieves superior patient risk-stratification, supporting precision medicine decisions. Abstract Epithelial ovarian cancer (EOC) remains a highly-lethal gynecological malignancy, characterized by frequent recurrence, ...