6. 巨噬细胞介导得脂质化凋亡肝细胞胞葬需有TREM2参与 FIG 5. TREM2 is essential for macrophage ef...
一些报告表明 TREM2 也可能识别非脂化 APOE，非脂化 APOE 是 Aβ 斑块的组成部分，可增强其致密性。
2d). In the macrophage study, sTREM2 did not detectably increase phosphorylated Akt, while in microglia, the anti-apoptotic effect was blocked with PI3K inhibitors and was mediated by Akt inhibition of glycogen synthase kinase 3 to increase β-catenin. sTREM2 also increased the transcription of...
单次跨膜的免疫球蛋白超家族跨膜受体ꎬ能够增强巨噬细胞吞噬能力并抑制其炎性激活ꎬ促进巨噬细胞中 的胆固醇流出ꎬ抑制其向泡沫细胞的转变ꎮ泡沫状ＴＲＥＭ２型巨噬细胞特异性存在于动脉粥样硬化的粥样 斑块中ꎮ此外ꎬＴＲＥＭ２脱落后形成的ｓＴＲＥＭ２亦表现出神经保护和促进炎症反应的功能ꎮ因此...
Geniposide (GP) can inhibit AS progression and enhance macrophage autophagy, although the underlying mechanisms remain unknown. We found that high-fat diet (HFD) feeding significantly increased TREM2 levels and inhibited autophagy in the macrophages of ApoE[Formula: see text] mice. TREM2 ...
macrophage activation. TREM2 is expressed on macrophages, immature myeloid dendritic cells, osteoclasts, microglia, and adipocytes. It promotes the differentiation and function of osteoclasts, the production of inflammatory cytokines by adipocytes, insulin resistance, and the phagocytic clearance of bacteria...
髓样细胞触发受体-2(TREM-2)是新近发现的免疫球蛋白受体,在炎症和免疫反应中扮演重要角色。近年来有研究表明,TREM-2在多种恶性肿瘤如肺癌、胃癌、肝癌、结直肠癌、肾癌、神经胶质瘤中异常表达,其可通过不同信号通路广泛参与恶性肿瘤的发生、发展、侵袭和转移过程。TREM-2可为恶性肿瘤的诊治及改善预后提供参考。 关...
has prompted in depth studies on the impact of TREM2 on microglia responses to pathological features of AD, including Aβ plaques, tauopathy and demyelination, which will be reviewed in the following sections. The broad role of TREM2 on macrophage functions in neurodegeneration, obesity, and ...
has prompted in depth studies on the impact of TREM2 on microglia responses to pathological features of AD, including Aβ plaques, tauopathy and demyelination, which will be reviewed in the following sections. The broad role of TREM2 on macrophage functions in neurodegeneration, obesity, and ...
6. 巨噬细胞介导得脂质化凋亡肝细胞胞葬需有TREM2参与FIG 5. TREM2 is essential for macrophage ...