2. TREM2 macrophages in acne lesions express lipid metabolism and inflammatory genes We focused on the role of TREM2 macrophage in acne because they were abundant in acne lesions as opposed to nonlesional skin. Fig 2a:展示了M1样巨噬、M2样巨噬和TREM2+巨噬的marker基因。 Fig 2b:TREM2+巨噬...
6. 巨噬细胞介导得脂质化凋亡肝细胞胞葬需有TREM2参与 FIG 5. TREM2 is essential for macrophage ef...
一些报告表明 TREM2 也可能识别非脂化 APOE，非脂化 APOE 是 Aβ 斑块的组成部分，可增强其致密性。
2d). In the macrophage study, sTREM2 did not detectably increase phosphorylated Akt, while in microglia, the anti-apoptotic effect was blocked with PI3K inhibitors and was mediated by Akt inhibition of glycogen synthase kinase 3 to increase β-catenin. sTREM2 also increased the transcription of...
macrophage activation. TREM2 is expressed on macrophages, immature myeloid dendritic cells, osteoclasts, microglia, and adipocytes. It promotes the differentiation and function of osteoclasts, the production of inflammatory cytokines by adipocytes, insulin resistance, and the phagocytic clearance of bacteria...
Disease severity was associated with elevated pro-inflammatory M1 macrophage markers like FCN1, STAT1, STAT2, NF-κB, IRFs, CCL2, CCL3, and CXCL10 as well as profibrotic M2 markers like SPP1, TGFB1, and TREM2. Healthy controls and the moderate groups were characterized by alveolar ...
TREM2介导小胶质细胞吞噬功能在神经退行性疾病中的作用 中国免疫学杂志2022年第38卷 TREM2介导小胶质细胞吞噬功能在神经退行性疾病中的作用① 韩 雪 夏天娇② 刘斌文 顾小萍（南京大学医学院附属鼓楼医院麻醉科，南京210008）中图分类号R392.2文献标志码 A 文章编号 1000-484X （2022）11-1388-07 ［摘 要］以...
Geniposide (GP) can inhibit AS progression and enhance macrophage autophagy, although the underlying mechanisms remain unknown. We found that high-fat diet (HFD) feeding significantly increased TREM2 levels and inhibited autophagy in the macrophages of ApoE[Formula: see text] mice. TREM2 ...
髓系巨噬细胞一类的细胞表面标志物marker，调控他们的凋亡增殖自噬和代谢
Macrophage-lineage-determining factor PU.1 (Heinz et al., 2010) cooperates with microglia-specific enhancer regions of the Mef2 family (Butovsky et al., 2014, Matcovitch-Natan et al., 2016). Mef2a might partner with PU.1 to establish a microglia-specific signature (Lavin et al., 2014)...