Specifically, if TREM-2 is mainly expressed on the surface of macrophages and microglia, it is supposed to alleviate the inflammatory response33,34,35,36. However, it will amplify the inflammatory response when it is mainly expressed on the surface of DCs23. Our study proved that TREM-2 was...
we identified senescent microglia that express high levels of TREM2 but also exhibit a distinct signature from TREM2-dependent disease-associated microglia (DAM). This senescent microglial protein signature was found in various mouse models that show cognitive decline, including aging, amyloidosis and ...
In the P301Lhemi hippocampus, phospho-tau immunostaining was detected in CA1/subiculum neurons by 4.5 months and progressed toward the CA1/CA3 border with age, also becoming prominent by the age of 9 months in mossy fiber axons extending from the dentate to CA3. These patterns, as well ...