TREM2 agonist-2 纯度:100% 产品编号T62750Cas号2738485-98-6 TREM2 agonist-2 (I-192) 是一种具有口服活性和高效性的髓系细胞触发受体 2 (TREM2) 激动剂 ,可用于研究神经退行性疾病。 规格价格库存数量 1 mg¥ 2,960现货 5 mg¥ 6,990现货...
TREM2 agonist-1用途 TREM2激动剂-1(I-246)是一种在髓样细胞2(TREM2)激动剂(EC50在3.0μM和100μM之间)上表达的触发受体[1]。 TREM2 agonist-1名称 [ CAS 号 ]:2738486-70-7 [ 英文名 ]: TREM2 agonist-1 TREM2 agonist-1生物活性
TREM2小分子激动剂 TREM2 agonist-1orb1687542 TREM2 agonist-2orb1687293 请持续关注我们每月的“文献分享”,获取更多不同科研领域的研究动态! 发布于 2024-04-19 14:35
化合物 TREM2 AGONIST-2 中文别名: TREM2 激动剂2;化合物 TREM2 AGONIST-2 CBNumber: CB010258222 分子式: C24H23ClFN5O 分子量: 451.92 MOL File: 2738485-98-6.mol 化学性质安全信息用途供应商4 化合物 TREM2 AGONIST-2化学性质 沸点: 584.0±50.0 °C(Predicted) ...
Using a Trem2 agonist antibody (AL002a, Alector Inc.), we treated Ldlr-/-mice that had preexisting atherosclerotic plaque with either isotype control or AL002a antibody for 8 weeks. AL002a treated mice showed an increase in plaque size in the aortic arch and aortic sinus. Plaque analysis...
化合物 TREM2 AGONIST-1 中文别名: 化合物 TREM2 AGONIST-1 CBNumber: CB312124580 分子式: C23H21ClFN5O 分子量: 437.9 MOL File: 2738486-70-7.mol 化学性质安全信息用途供应商1 化合物 TREM2 AGONIST-1化学性质 沸点: 592.0±50.0 °C(Predicted) ...
Thus, we tested the hypothesis that administration of a Trem2 agonist antibody (AL002a) to atherogenic mice would enhance macrophage survival and decrease necrotic core formation to improve plaque stability.#To model a therapeutic intervention approach, atherosclerosis-prone mice (Ldlr [low-density ...
[1] Juric V, Mayes E, Binnewies M, et al P02.11 TREM1 agonist PY159 promotes myeloid cell reprogramming and unleashes anti-tumor immunity Journal for ImmunoTherapy of Cancer 2021;9:doi: 10.1136/jitc-2021-ITOC8.23 [2] Deczkowsk...
[1] Juric V, Mayes E, Binnewies M, et al P02.11 TREM1 agonist PY159 promotes myeloid cell reprogramming and unleashes anti-tumor immunity Journal for ImmunoTherapy of Cancer 2021;9:doi: 10.1136/jitc-2021-ITOC8.23 [2] Deczkowska A, Weiner A, Amit I. The Physiology, Pathology, and...
Although we did not observe an impairment of signalling upstream of PLCγ2 using TREM2-activating antibody as a TREM2 agonist, the TREM2 antibody is a high-affinity ligand and may saturate TREM2 downstream signalling even when receptor numbers are reduced. In contrast, phagocytic cargo such as...