Localization of sTREM2 In general, sTREM2 is released into the extracellular or luminal space [25]. Depending on the cellular context, sTREM2 secretion varies, and it can settle into different extracellular spaces. For instance, microglial TREM2 is cleaved and secreted into the brain parenchyma...
In some embodiments, compound that increases the activity of TREM2 is an agonist of TREM2. In some embodiments, the agonist of TREM2 is a small molecule agonist of TREM2 or an antibody agonist of TREM2.
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Moreover, increasing TREM2 function pharmacologically by agonist mAbs improved microglia oAβ phagocytosis [42, 67]. oAβ-LILRB2 binding has been shown to play a role in neurological function [16]. The mouse LILRB2 ortholog, PirB, is expressed on neuronal growth cones and is associated with ...
siRNA: Small interfering RNA TNF: Tumor necrosis factor TREM2: Triggering receptor expressed on myeloid cells 2 TUNEL: Terminal deoxynucleotidyl transferase dUTP nick end labeling References Li X, Feng D, Chen G. An update on medical treatment for intracerebral hemorrhage. Transl Stroke Res. ...
In some embodiments, compound that increases the activity of TREM2 is an agonist of TREM2. In some embodiments, the agonist of TREM2 is a small molecule agonist of TREM2 or an antibody agonist of TREM2.PAPAPETROPOULOS, SPYRIDONFISHER, RICHARD...
Finally, TREM2 variant carriers further complicate our under- standing of this molecule, as some TREM2 mutants have a strong impact on the sTREM2 level in myeloid cells [42]. TREM2 variants can upregulate or downregulate protein cleavage or influence the shedding of sTREM2 into body fluids ...
Our findings represent the first report of endocrine regulation of TREM2 and provide a unique opportunity to drug the TREM2 signaling pathway with orally active small molecule therapeutic agents.doi:10.1101/2021.01.25.428149Skylar J FerraraPriya Chaudhary...
In some embodiments, compound that increases the activity of TREM2 is an agonist of TREM2. In some embodiments, the agonist of TREM2 is a small molecule agonist of TREM2 or an antibody agonist of TREM2.BRENNAN, MATTHEWDUNN, JUDITH
In some embodiments, compound that increases the activity of TREM2 is an agonist of TREM2. In some embodiments, the agonist of TREM2 is a small molecule agonist of TREM2 or an antibody agonist of TREM2.MATTHEW BRENNANJUDITH DUNNRICHARD FISHER...