117 INVITED Treatment options for glioblastoma failing standard first-line treatmentdoi:10.1016/s1359-6349(07)70231-8W. Wick
Specifically, the invention is directed to the use of endocrine modulators and drug combinations in providing improved therapy for patients afflicted with brain tumors such as glioblastomas.BACKGROUND OF THE INVENTIONGlioblastoma multiforme (GBM, also known as glioblastoma and grade IV astrocytoma) is a...
The WHO classifies glioblastoma as a Grade IVtumour, indicating its highly aggressive nature. Unlike other cancers, glioblastomasare not stagedlike other tumours, but their grade reflects their severity and rapid growth potential, guiding treatment decisions. Treatment options in gl...
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults. Current treatment options at diagnosis are multimodal and include surgical resection, radiation, and chemotherapy. Significant advances in the understanding of the molecular pathology of GBM and associated cell signaling...
The figures above indicate that the demand for treatment is likely to increase exponentially, which, in turn, is projected to augment the global glioblastoma multiforme (GBM) treatment market. R&D Helps Accelerate Treatment Options for Glioblastoma Multiforme Companies in the glioblastoma multiforme (GBM...
It focuses on results from recent studies in newly diagnosed glioblastoma, and the role of temozolomide in MGMT-unmethylated patients. We then turn the discussion to alternatives to temozolomide for newly diagnosed patients as well as therapeutic options at the time of recurrence.Jennie W. Taylor...
Introduction: Glioblastoma is invariably deadly and is characterized by extensive vascularization and macrophage-dominant immunosuppression; nevertheless, anti-angiogenesis has so far failed to prolong overall survival of patients. Regardless of the problems in clinical development, the rationale for the ...
Background: Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults. Current treatment options at diagnosis are multimodal and include surgical resection, radiation, and chemotherapy. Significant advances in the understanding of the molecular pathology of GBM and associated ...
The adaptability of glioblastoma (GBM) cells, encouraged by complex interactions with the tumour microenvironment (TME), currently renders GBM an incurable cancer. Despite intensive research, with many clinical trials, GBM patients rely on standard treat
For example, Smac mimetics have recently been shown to synergize with immune checkpoint inhibitors to suppress tumor growth in mouse models of glioblastoma23. Such strategies may pave the avenue for new options for the treatment of patients suffering from glioblastoma....