The present invention relates to treatment or prevention of radiation induced fibrosis using TNF-alpha antagonism. Preferably, TNF-alpha is antagonized by direct binding or by inhibition of synthesis. In a preferred embodiment, the invention comprises intraperitoneal administration of a chitosan-siRNA ...
There is a definite increase in combined-modality treatment of malignancies. Surgery, radiation therapy, and/or chemotherapy often are combined. A disadvantage is the increased risk for short- and long-term complications, especially radiation-induced damage to normal healthy tissue such as intestine an...
Variation in sensitivity to radiation is an inherited genetic trait. This Perspective explores the possibility of genome-wide association studies to characterize genetic profiles that predict patient response to radiotherapy. A key challenge in radiother
Post-operative radiation therapy has been shown to be safe and effective in reducing recurrence of keloids after excision surgery. In addition, it has been reported that post-operative radiation therapy is a simpler treatment modality with better patient compliance than post-operative corticosteroid inje...
Ferroptosis, a new form of regulated cell death (RCD), is driven by iron-dependent lipid peroxidation (LPO) of polyunsaturated fatty acid-containing phospholipids (PUFA-PLs) in cellular membranes.1,2,3,4Ferroptosis was first reported in 2012 and was found to be induced by erastin, an oncogeni...
Radiation-induced vascular effects At present, radiation is used as one of the common forms of cancer treatment. It has been well established that radiation act primarily by inducing DNA damage, subsequently causing cancer cell death [1], [2], [3]. Some studies, on the other hand, suggest...
A colony-forming assay of human skin fibroblast radiosensitivity was established in our laboratory and applied to primary skin biopsies from 12 women belon... J Johansen,SM Bentzen,J Overgaard,... - 《International Journal of Radiation Biology》 被引量: 192发表: 1994年 Growth of Pseudomonas aer...
Cheng W, Xiao L, Ainiwaer A, Wang Y, Wu G, Mao M, Yang Y, Bao Y. Molecular responses of radiation induced liver damage in rats. Mol Med Rep. 2015;11:2592–600. CAS PubMed Google Scholar Download references Acknowledgements Not applicable. Funding This work was supported by the Open...
& Lu, Y. Ionizing radiation-induced cellular senescence in normal, non-transformed cells and the involved DNA damage response: a mini review. Front. Pharmacol. 9, 522 (2018). Article PubMed PubMed Central CAS Google Scholar Canavese, M., Santo, L. & Raje, N. Cyclin dependent kinases ...
Breast Skin Flap Ischemia and Necrosis Pain out of proportion associated with a violaceous ischemic hue occurring acutely due to implant overexpansion or sub-acutely due to radiation-induced tissue contraction. Immediate resolution of symptoms following implant decompression. If partial or full thickness...