Radiation-induced lung fibrosis after treatment of small cell carcinoma of the lung with very high-dose cyclophosphamide. Cancer 1985; 55: 57 - 60Trask CWL, Joannides T, Harper PG, et al: Radiation- induced lung fibrosis after treatment of small cell carcinoma of the lung with very hig...
This is also seen in the contralateral untreated lung. Increased understanding of these mechanisms will suggest new strategies for improving the efficacy of radiation therapy while limiting toxic side effects. 展开 关键词: Radiation Radiation pneumonitis Pulmonary fibrosis.....
Replacement of normal lung parenchyma by fibrosis is the culminating event. Depending on the dose and volume of lung irradiated, acute radiation pneumonitis may develop, characterized by dry cough and dyspnea. Fibrosis of the lung, which can also cause dyspnea, is the late complication. Imaging ...
Radiation has been attributed to numerous types of long-term cardiovascular disease, including pericarditis, coronary artery disease, and myocardial fibrosis [79]. The association between low-dose IR exposure and cardiovascular risk remains contested [80,81,82]. In fact, select studies have recently ...
Studies have demonstrated that M1 macrophages promote inflammation and inhibits fibrosis [23]. Interestingly, LPS treatment (induces macrophage polarization to M1 type) attenuates early radiation damage to the lung [37]. Radiation-induced early inflammation plays a minimal role in the later development ...
Fibrosis is a common sequela of both cancer treatment by radiotherapy and accidental irradiation and has been described in many tissues, including skin (Brocherion et al. 1986), lung (Bentzen et al. 1989), heart (Lopez Cardoso et al. 1985) and liver (Fajardo and Stewart 1973). Fibrotic ...
Radiation-induced changes in lung tissue and development of fibrosis determined by quantitative morphometric methods 来自 掌桥科研 喜欢 0 阅读量: 23 作者:R Kraus,F Steinberg,B Rehn,J Bruch,C Streffer 摘要: This study presents results of morphometric investigations of mouse lungs after single ...
Hill RP (1983) Reponse of mouse lung to irradiation at different dose rates. Int J Radiat Oncol Biol Phys 9: 1043–1047 PubMed CAS Google Scholar Hines LE (1922) Fibrosis of the lung following roentgen- ray treatment for tumor. JAMA 79: 720–722 Google Scholar Hirst DG, Denekamp J,...
lung in patients who received oblique radiation therapy for thetreatment of lung cancer. This process takes the form of a limited, whorled or convoluted area of fibrosis developing afterstereotactic body radiation therapy, or it can be diffuse when occurring after whole-lung or total-body ...
Radiation therapy is the mainstay in the treatment of lung cancer, and lung fibrosis is a radiotherapy-related major side effect that can seriously reduce patient’s quality of life. Nevertheless, effective strategies for protecting against radiation therapy-induced fibrosis have not been developed. ...