Congenital long QT syndrome (LQTS) is an inherited arrhythmia syndrome characterized by prolonged QT interval, and an increased risk of polymorphic ventricular tachycardia and sudden cardiac death. The identification and in-depth scientific study of gene mutations associated with this syndrome have ...
The QT interval is just one important determinant of the risk of TdP and other risk factors should also be taken into account when planning patient management. In aLQTS the arrhythmia is more likely to occur in those with bradycardias or pauses because impairment of IKr produces a prolonged an...
effectiveness of magnesium sulfate given by slow infusion and evaluate its influence on ventricular repolarisation parameters, we enrolled 12 consecutive patients (9 men and 3 women; aged 49 to 78 years) with acquired prolonged QT interval (QTc = 500 to 640) and episodes of torsade de pointes...
RESULTS: The QTc interval was prolonged (> 450 ms in men, > 470 ms in women) in 21% of the patients before antiemetic drug administration. This was significantly correlated with lower body temperature and longer duration of anesthesia. Compared with predrug QTc measurement, both antiemetics ...
orally administered quizartinib prolonged QTc at ≥ 10 mg/kg and increased systemic blood pressure at ≥ 100 mg/kg [54]. Additional toxicology studies of quizartinib were conducted in rats, dogs, and monkeys. In all animal species studied, the principal target organs of toxicity were ...
However, LAAM is associated with prolonged QT interval, and several cases of cardiac arrhythmia and death have been reported. Therefore, LAAM was recently removed from the market in the European Union and was given a black box label by the FDA. Several Cochrane Database Systematic Reviews ...
antioxidants Article Combined Treatment with Bojungikgi-Tang and Riluzole Regulates Muscle Metabolism and Dysfunction in the hSOD1G93A Mouse Model Mudan Cai and Eun Jin Yang * KM Science Research Division, Korea Institute of Oriental Medicine (KIOM), Yuseong-daero 1672, Yuseong-gu, Daejeon 34054,...
Associations Between Abnormal ECG (Prolonged QT or Arrhythmia) and Patient Characteristics eTable 6. Alternative Model Results for In-Hospital Death eTable 7. Model-Adjusted Risk of In-Hospital Death, Cardiac Arrest, Arrhythmia – Models Stratified by Receipt of Mechanical Ventilation ...
Common adverse events included HLS, APL differentiation syndrome, a prolonged QT interval on electrocardiography, skin rash, and hyperglycemia. The occurrence of some toxic events including gastrointestinal disturbance, facial edema, and cardiac toxicity seemed less severe in the group given low-dose As2...
36, 37, 38 The extrapyramidal side effects of pimozide are fewer than those of haloperidol, but potential cardiac side effects of prolonged QT and arrhythmia limit its use in children. Chlorpromazine Chlorpromazine was the first antipsychotic drug discovered in 1950 and is considered as one of the...