It also reviews some major implications of ECG monitoring in the field, including interpretation of ECGs and QTc intervals, management of patients with prolonged QTc intervals, and contextualizing the risk of QTc prolongation for patients being treated for MDR-TB. 展开 ...
In addition to known side effects such as retinal toxicity and neuromusculopathy, prolongation of the QT interval is mentioned in multiple studies. The QT interval can be prolonged due to comorbidities, medication or dyselectrolytemia. QT corrected interval (QTc) durations greater than 470...
RESULTS: The QTc interval was prolonged (> 450 ms in men, > 470 ms in women) in 21% of the patients before antiemetic drug administration. This was significantly correlated with lower body temperature and longer duration of anesthesia. Compared with predrug QTc measurement, both antiemetics ...
The rate-corrected electrocardiographic QT (QTc) interval may significantly increase in patients with schizophrenia taking antipsychotics. The objective of this naturalistic study was to assess the prevalence of prolonged QTc interval in a large population of inpatients with chronic schizophrenia and to exp...
orally administered quizartinib prolonged QTc at ≥ 10 mg/kg and increased systemic blood pressure at ≥ 100 mg/kg [54]. Additional toxicology studies of quizartinib were conducted in rats, dogs, and monkeys. In all animal species studied, the principal target organs of toxicity were ...
Prolongation of the QT interval corrected for heart rate (QTc >0.43 milliseconds) was observed in 10% of patients in both groups at baseline. At 8 weeks, prolonged QTc interval was observed in 4% of patients in the full-dose group and 13% of patients in the low-dose group. Exercise ...
A review of its antibacterial activity, pharmacokinetic properties, clinical efficacy and tolerability in lower respiratory tract infections. Its long elimination half-life permits once-daily dosage regimens. On the other hand, there are infrequent reports of prolonged QTc interval (3% increase)... KL...
QTc prolongation, and fatigue [130]. Among these, QTc prolongation which significantly increased during treatment with vandetanib should be well-considered due to its life-threatening effect [131]. Genetic alterations, including DNA mutations and epigenetic modifications, contribute to the resistance of ...
lenvatinib also significantly improved the PFS in this subgroup of patients (15.1 vs 3.6 months; HR 0.22; 95% CI 0.12–0.41) and increased response rates (62.1 vs. 3.7 %).48 Complete radiologic responses were seen in four patients, and prolonged stable disease (longer than 23 weeks) was no...
Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol 2006; 47: 362–367. 25 Chapman N, Mayet J, Ozkor M, Lampe FC, Thom SA, Poulter NR. QT intervals and QT dispersion as measures of left ventricular hypertrophy in an unselected ...