molecular weight, number of hydrogen bond donor (HBD) and hydrogen bond acceptor (HBA) atoms, number of rotatable bonds, cLog P, pK a, topological polar surface area (tPSA), metabolic stability, and effective permeability to within the generally accepted parameters for successful CNS-directed...
Despite numerous clinical trials and decades of endeavour, there is still no effective cure for Alzheimer's disease. Computational drug repositioning approaches may be employed for the development of new treatment strategies for Alzheimer’s patients sin
The PSA test is a tool for use by your doctor, but it is not a perfect way to tell whether or not a patient has prostate cancer because is not sensitive enough to pick up all prostate cancers. It is not specific enough in that it may be elevated in people without prostate cancer, s...
The PSA test is a tool for use by your doctor, but it is not a perfect way to tell whether or not a patient has prostate cancer because is not sensitive enough to pick up all prostate cancers. It is not specific enough in that it may be elevated in people without prostate cancer, s...
Juvenile Idiopathic Inflammatory Myopathies (IIM) are a group of rare diseases that are heterogeneous in terms of pathology that can include proximal muscle weakness, associated skin changes and systemic involvement. Despite options for treatment, many patients continue to suffer resistant disease and ...
for older men, regular examination of theprostate glandwith blood tests for prostate-specific antigen (PSA) tumor marker (a substance in the body that heralds an increased cancer risk). A fecal immunochemical test (FIT) or colonoscopy plus physical examination and laboratory tests for carcinoembryoni...
DRE should not be used as a stand-alone test for detection of prostate cancer but should be performed in men with an elevated PSA. The NCCN also notes that DRE may be considered as a baseline test in all patients, as it may help identify high-grade cancers associated with a normal PSA...
For example, the Rowasa enema is a 5-ASA solution that is effective in treating inflammation in and near the rectum (ulcerative proctitis and ulcerative proctosigmoiditis). However, the enema solution cannot reach high enough to treat inflammation in the upper colon. Therefore, for most patients...
Active surveillance is ideally suited for individuals with other life-threatening medical conditions and older patients whose bodies would not be able to handle the trauma of surgery or vigorous therapies. Obviously, if the PSA velocity increases rapidly, then a course of treatment needs to be put...
The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of malignancies of the central nervous system in pediatric patients, including glioblastoma multiforme (GBM) high grade glioma, and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7...