METHODS OF TREATING MULTIPLE MYELOMA CANCERS EXPRESSING HIGH LEVELS OF EPO-RECEPTOR USING PSA-EPOThe present invention demonstrates that erythropoietin (EPO)-receptor (EPOR) is a malignant myeloma biomarker of sensitivity to EPO treatment and, itself a target for myeloma treatment. A low EPOR level ...
Gomella, MD. At this point, if you are going to use sipuleucel-T, this is the best opportunity to administer the treatment. According to an exploratory analysis that divided PSA levels in the IMPACT trial into quartiles, the survival advantage with sipuleucel-T when the PSA was below 22 w...
The study involved more than 82,000 men in the United Kingdom, aged 50 to 69, who had tests for PSA, or prostate specific antigen. High levels can signal prostate cancer but also may signal more harmless conditions, including natural enlargement that occurs with age. Researchers focused...
Comorbidities and concomitant medication use in men with prostate cancer or high levels of PSA compared to matched controls: a GPRD analysis. J Cancer Epidemiol 2012;2012:291704. Article PubMed PubMed Central CAS Google Scholar Fleshner K, Tin A, Benfante N, Carlsson S, Vickers AJ. ...
Compared to the prostate cancer patients who only received a single drug therapy during their year of treatment, patients who received either one or two additional drugs stayed cancer-free, with low PSA levels, for longer. Once off the treatment, patients who took the combination therapies s...
PSA 90 ng/mL; Hb 9.4 g/dL; ANC 1.5 Liver function tests continue to be abnormal Diagnosis of Recurrence Patient is diagnosed with biochemical recurrence of prostate cancer with high-volume castration-sensitive metastatic disease Germline genetic testing is negative ...
High expression of TGFβ1 in LIHC was associated with decreased OS compared to LIHC expressing low levels of TGFβ1 (median, 47 months and 70 months, respectively). See FIGS. 1A and 1B. TGFβ gene signaling was increased in primary solid tumors 1.1317 fold compared to normal tissue. High...
Steady or reduced PSA levels below an age-dependent threshold (normal PSA levels increase with age) may indicate an effective treatment. When a PSA level remains steady at a low level (e.g., lower than 4.0 ng/mL), this can indicate that a treatment is effective and/or that the prostate...
33% (58 out of 176) for the high risk patients (p < or = .001). Excluding the SV from the treatment field can significantly reduce (40%-50%) the volume of irradiated rectum. Our data confirm that pretreatment PSA levels and Gleason scores can be effectively used to define subgroups ...
It is thus assumed that the aforementioned effects of diacerein on cytokines is one of a possible reason for its effectiveness in the treatment of psoriasis since there is an expression of high levels of TNF-α, IL-1, IL-6 and IL-8 in the synovial fluid of patients suffering from psoriasi...