Furthermore, our understanding of the role of translation in cancer development and progression, as well as its significance in clinical medicine has also greatly increased. The process of messenger RNA (mRNA) translation is comprised of four main stages: initiation, elongation, termination and ...
Brown CM, Stockwell PA, Trotman CNA, Tate WP: Sequence analysis suggests that tetra-nucleotides signal the termination of protein synthesis in eukaryotes. Nucl Acids Res 18: 6339–6345 (1990). PubMedCASGoogle Scholar Brown CM, Dalphin ME, Stockwell PA, Tate WP: The translational termination si...
Diversity of tRNA genes in eukaryotes. Nucleic Acids Res. 34, 6137–6146 (2006). CAS PubMed PubMed Central Google Scholar Budde, B. S. et al. tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. Nat. Genet. 40, 1113–1118 (2008).This study provides the link between ...
Translation Elongation and Recoding in Eukaryotes 来自 NCBI 喜欢 0 阅读量: 48 作者:TE Dever,JD Dinman,R Green 摘要: Protein synthesis that does not initiate with methionine is used by the mammalian immune system to process antigen.DOI: 10.1101/cshperspect.a032649 被引量: 5 ...
It is these key differences in how individual mRNAs are translated that provide some basis of differential regulation of translation by ER-bound regulatory factors. 4.1 Cap-dependent and elongation translational control Translation initiation in eukaryotes is a complex process that provides opportunity for...
Compare translation in eukaryotes and prokaryotes The synthesis of proteins consumes more of a cell’s energy than any other metabolic process. In turn, proteins account for more mass than any other macromolecule of living organisms. They perform virtually every function of a cell, serving as both...
What is clear from the many decades of studies on NMD is that the process is intimately coupled to translation termination. Termination of protein synthesis occurs when one of three nearly universal stop codons (UAG, UGA, and UAA) enter the A site of the ribosome. In eukaryotes, termination ...
Although recent biochemical and genetic investigations have produced some insights into the mechanism of initiation of translation in eukaryotic cells, two aspects of the initiation process remain controversial. One unsettled issue concerns a variety of functions that have been proposed for mRNA binding pr...
Synthetic posttranscriptional regulation of gene expression is important for understanding fundamental biology and programming new cellular processes in synthetic biology. Previous strategies for regulating translation in eukaryotes have focused on disru
In eukaryotes, the eukaryotic translation elongation factor eEF1A responsible for transporting amino-acylated tRNA to the ribosome forms a higher-order com... F Mansilla,I Friis,M Jadidi,... - 《Biochemical Journal》 被引量: 72发表: 2002年 Functional mapping of the translation-dependent instabili...