1Overview of initiation of protein synthesis Protein synthesis(or translation) is a recurring process going on through initiation, elongation, termination and recycling. As one of the most energetically expensive cellular processes, it is tightly regulated, predominantly at the initiation step by...
The linear amino acid sequence of a protein is encoded within the gene as a linear deoxyribonucleotide sequence. Early steps in the biosynthesis of a protein include transcription of the gene and appropriate processing of the transcript leading to the production of mature messenger RNA (mRNA). We...
We have deleted the chromosomal rpsA gene, encoding ribosomal protein S1, from an Escherichia coli strain carrying a plasmid where rpsA was controlled by the lac promoter and operator. This exogenous source of protein S1 was essential for growth. Thus we have verified the absolute requirement for...
3.PhysicsMotion of a body in which every point of the body moves parallel to and the same distance as every other point of the body. 4.BiologyThe process by which messenger RNA directs the amino acid sequence of a growing polypeptide during protein synthesis. ...
of different substrates. The translocon-associated protein complex (TRAP), a hetero-tetrameric transmembrane protein complex supporting the insertion of many signal peptides10,11, is a near-stoichiometric ER translocon component12. Low-resolution studies revealed interactions of TRAP with ribosomal RNA ...
第十二章蛋白质生物合成(翻译)Protein Biosynthesis (Trans... 热度: Proteintranslation thelaststepoftheconversionofthegeneticinformation(storedinalinearnucleotidesequence)ontheDNAandtranscribedintoasingle-strandedmessengermolecule(mRNA)intoafunctionalpolypeptidechain(calledproteinorenzyme)biologistscallproteintransla...
Codon assignments and fidelity of translation in a cell-free protein-synthesizing system from an extremely halophilic bacterium. The incorporation of 14C-labelled amino acids into material insoluble in hot TCA under the direction of synthetic polyribonucleotides has been studied in a preincubated, cell...
Techniques for systematically monitoring protein translation have lagged far behind methods for measuring messenger RNA (mRNA) levels. Here, we present a ribosome-profiling strategy that is based on the deep sequencing of ribosome-protected mRNA fragments and enables genome-wide investigation of translatio...
a transformation in which every point of a geometric figure is moved the same distance in the same direction. Genetics.the process by which amessenger RNAmolecule specifies the linear sequence of amino acids on a ribosome for protein synthesis. Comparegenetic code ( def ). ...
Prostate tumor overexpressed-1 (PTOV1), a modulator of the Mediator transcriptional regulatory complex, is expressed at high levels in prostate cancer and other neoplasias in association with a more aggressive disease. Here we show that PTOV1 interacts directly with receptor of activated protein C...