Translating preclinical models to humans Authors Douglas K. Brubaker, Douglas A. Lauffenburger Generalizing results from animal models to human patients is a critical biomedical challenge. This problem is a key cause of the large proportion of failures encountered in moving therapeutics from preclinical...
Preclinical models of alcohol use disorder (AUD) have advanced theoretical, mechanistic, and pharmacological study of the human condition. "Liking" and "wanting" behaviors reflect core processes underlying several models of AUD. However, the development and application of translational models of these ...
Ultimately, high quality in vitro and in vivo data will aid in the establishment of physiologically based pharmacokinetic (PBPK) models, which will improve the capability to predict PK characteristics of drug candidates in humans. 展开 关键词: drug transporters drug-drug interactions pharmacokinetics ...
These animal models are precisely defined in the context of a uniform genotype and a uniform environment but stand in stark contrast to humans, who have a comparatively varied genetic composition, highly variable diet, and exposure to an array of environmental stresses. Well-known structural and ...
We then report the latest developments and clinical utilisation of this innovative technology to gain a better understanding of its impact on the management of CNS disorders and injuries in humans. Finally, current challenges and future directions are posed to drive the continued translation of ...
Translating initial concepts into advanced technologies treating diseases in preclinical models and finally into functional and marketable products for humans can be particularly daunting. While referring to specific ophthalmic companies and products, this review considers key exchanges that lead to successful...
The αβTCR of NKT cells expresses the invariant TCR Vα24 chain, characterized by their usage of the Jα18 segment in humans. Most NKT cells recognize through their αβTCR lipids expressed within the context of CD1c or CD1d. Cytotoxic type 1 phenotype Ability in αβ and γδ T cells...
IL-17-producing γδ T cells have proven difficult to find in humans [30,31,60,61,77]. Nonetheless, several pieces of evidence support a local, tissue-resident γδ T cell compartment with cancer immunosurveillance capacity in humans. γδ T cells have been found in multiple human tissues ...
The ensuing frustration on the part of researchers and developers may be the result of failure to fully comprehend what is required to assure that confidence. 展开 关键词: Humans Stem Cell Transplantation Stem Cell Research Cell- and Tissue-Based Therapy Stem Cells ...
To enhance the confidence for identification of drugs that cause severe DILI in humans, the “Rule of Three” was developed in DILIps by using a consensus strategy based on 13 models. This gave high positive predictive value (91%) when applied to an external dataset containing 206 drugs ...