ClinicalCardiovascular (CV) safety-related attrition is an important contributor to the loss of promising drug candidates during development. CV safety pharmacology studies are conducted to identify these safety effects. Understanding translation of CV endpoints (specifically, heart rate [HR], and blood ...
While hundreds of interventions have demonstrated preclinical efficacy for ameliorating cognitive impairments in animal models, none have confirmed efficacy in Alzheimer's disease (AD) clinical trials. Critically this lack of translation to the clinic points in part to issues with the animal models, ...
A mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) model was used for preclinical to clinical translation of inotuzumab ozogamicin, a CD22-targeting antibody-drug conjugate (ADC) for B cell malignancies including non-Hodgkin's lymphoma (NHL) and acute lymphocytic leukemia (ALL). Preclinical dat...
Define preclinical. preclinical synonyms, preclinical pronunciation, preclinical translation, English dictionary definition of preclinical. adj. 1. Of or relating to the period of a disease before the appearance of symptoms. 2. Of or relating to research
Interventional cardiac magnetic resonance imaging in electrophysiology: advances toward clinical translation Circ Arrhythm Electrophysiol, 8 (2015), pp. 203-211 Google Scholar 27 A. Arujuna, R. Karim, D. Caulfield, et al. Acute pulmonary vein isolation is achieved by a combination of reversible an...
The present concise review will focus on publications relating to these ongoing clinical trials, their outcomes, and the future clinical translation of adipose-derived, cell-based tissue engineering. Background Both ASCs and SVF cells have been used in preclinical models to treat acute and chronic ...
Receptor affinity and potency of non-steroidal antiandrogens: translation of preclinical findings into clinical activity. Prostate Cancer Prostatic Dis. 1998;1(6): 307-314.Kolvenbag GJ, Furr BJ, Blackledge GR. Receptor affinity and potency of non-steroidal antiandrogens: translation of preclinical ...
clinical translation at the forefront. Alongside rodent models, we offer pig models that are highly advantageous for evaluating pain, wound healing, PK and GLP toxicology. We work with domestic pigs and Gottingen minipigs, both of which have a close resemblance to human skin and neurological ...
Dienstmann R, Felip E. Necitumumab in the treatment of advanced non-small cell lung cancer: translation from preclinical to clinical development. Expert Opin Biol Ther 2011; 11: 1223-31.Dienstmann R1, Felip E. Necitumumab in the treatment of advanced non-small cell lung cancer: translation from...
Photoacoustic computed tomography (PACT) has generated increasing interest for uses in preclinical research and clinical translation. However, the imaging depth, speed, and quality of existing PACT systems have previously limited the potential applications of this technology. To overcome these issues, we...