One of the major problems in the translation of successful preclinical results to clinical studies and new therapies in Parkinson's disease is the use of preclinical models based on exogenous neurotoxins that do not replicate what happens in the disease. The loss of dopaminergic neurons containing ...
Free Essay: This disease is broken down into three stages the first being preclinical Alzheimer's disease, then mild cognitive impairment and lastly,...
I have always valued deep understanding, critical thinking, and problem solving, which are skills that I hope to develop and nurture in the clinical medicine students at CUHK-Shenzhn during their preclinical years. With the growing amount of literature and data in the medical field,...
The retina is also more accessible than other areas of the central ner- vous system, thus making it a simpler model to work with and study. By utilizing the retinal model, we can greatly increase our knowl- edge of the cell death processes initiated by ischemia which lead to degeneration ...
Is their preclinical eye not sufficiently trained, have they not been taught how to observe carefully, do they have insufficient knowledge of the normal anatomy, or have they seen too few abnormalities? In a pilot study we addressed the question of whether students can describe and correctly ...
"CRISPR repair reveals causative mutation in a preclinical model of retinitis pigmentosa." Molecular Therapy 24.8 (2016): 1388-1394. Yin, Hao, et al. "Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo." Nature biotechnology 34.3 (2016): 328...
Ban F, Dalal K, Li H, LeBlanc E, Rennie PS, Cherkasov A (2017) Best practices of computer-aided drug discovery: lessons learned from the development of a preclinical candidate for prostate cancer with a new mechanism of action. J Chem Inf Model 57(5):1018–1028 [cito:citesAsAuthority]...
Phase 0 studies, also known as human micro-dosing studies, use only a small dose of the new drug in fewer than 15 patients over a short period of time. The goal is to determine if the new drug or agent behaves in human subjects as is expected based on preclinical studies. ...
Small-cell lung cancer (SCLC) is a deadly cancer associated with smoke exposure that has neuroendocrine (NE) cell properties and is pathologically, molecularly, biologically and clinically very different from other lung cancers. While most patients with SCLC respond initially to cytotoxic therapy, almo...
With rising life expectancy, a longer disease duration in PD patients is observed, further increasing the need and socioeconomic importance of adequate PD treatment. Today, PD is exclusively treated symptomatically, mainly by dopaminergic stimulation, while efforts to modify disease progression could ...