Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechanisms and complexity of linkage disequilibrium (LD), the biological ...
Transcriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and gene expression datasets to identify gene–trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes at GWAS loci, by using simulations and...
蓝色和绿色基因均是通过TWAS鉴定出来的与GWAS相关的基因 灰色点表示原始的 GWAS P 值 蓝色点表示校正了绿色基因后的 GWAS P 值 如图所示,经校正后。灰色的点变成了蓝色点(显著变为不显著),说明绿色基因影响了GWAS表型。 http://gusevlab.org/projects/fusion/...
Recently, transcriptome-wide association studies (TWAS), which integrate data from GWAS and tissue gene expression datasets, have emerged as an effective approach to identify gene-trait associations.26,27,28,29,30 The current study builds on our previous GWAS meta-analysis of migraine20 that also...
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies (TWAS
Transcriptome-wide association studies (TWASs), like genome-wide association studies (GWASs), are a useful hypothesis-free method of studying how genetic variation influences a trait. Both GWAS and TWAS have been central to the study of psychosis, having identified 145 genetic loci and 175 genes...
Root system architecture plays a crucial role in nutrient and water absorption during rice production. Genetic improvement of the rice root system requires elucidating its genetic control. Genome-wide association studies (GWASs) have identified genomic r
Genome-wide association studies (GWASs) have identified thousands of genetic variants that are associated with many complex traits. However, their biological mechanisms remain largely unknown. Transcriptome-wide association studies (TWAS) have been recently proposed as an invaluable tool for investigating ...
However, current studies have found a limited number of SpA-related genes, and the genetic and pathogenic mechanisms of SpA are still unclear. Methods A tissue-specific transcriptome-wide association study (TWAS) of SpA was performed using GWAS (including 3966 SpA patients and 448,298 controls) ...
Fig. 3: Transcriptome-wide association study (TWAS) for SPP and enrichment analysis of TWAS significant genes. aManhattan plot of TWAS for SPP. TWASZ-scores (y-axis) are plotted against gene positions (x-axis) on each of the chromosomes. The gray dashed lines indicate theZ-scores at the...