transcriptome-wide association studies (TWAS) can help identify susceptibility genes associated with pathogenesis and disease behavior. In this review, we overview seven reported TW
GENOME-wide association studiesPHENOTYPESGenome-wide association study has identified fruitful variants impacting heritable traits. Nevertheless, identifying critical genes underlying those significant variants has been a great task. Transcriptome-wide association study (TWAS) is an instrumental post-analysis to...
蓝色和绿色基因均是通过TWAS鉴定出来的与GWAS相关的基因 灰色点表示原始的 GWAS P 值 蓝色点表示校正了绿色基因后的 GWAS P 值 如图所示,经校正后。灰色的点变成了蓝色点(显著变为不显著),说明绿色基因影响了GWAS表型。 http://gusevlab.org/projects/fusion/...
Genome-wide association studies (GWAS) have identified several loci associated with ADHD. However, understanding the biological relevance of these genetic loci has proven to be difficult. Here, we conduct an ADHD transcriptome-wide association study (TWAS) consisting of 19,099 cases and 34,194 ...
Root system architecture plays a crucial role in nutrient and water absorption during rice production. Genetic improvement of the rice root system requires elucidating its genetic control. Genome-wide association studies (GWASs) have identified genomic r
Transcriptome-wide association studies (TWASs) aim to integrate genome-wide association studies with expression-mapping studies to identify genes with genetically predicted expression (GReX) associated with a complex trait. In the present report, we deve
However, current studies have found a limited number of SpA-related genes, and the genetic and pathogenic mechanisms of SpA are still unclear. Methods A tissue-specific transcriptome-wide association study (TWAS) of SpA was performed using GWAS (including 3966 SpA patients and 448,298 controls) ...
TWAS can improve the power of genome-wide association studies (GWAS) while providing biological insights into the genes and regulatory mechanisms underlying disease. However, conventional TWAS approaches do not account for cell-type heterogeneity of bulk tissue samples, which can reduce the accuracy of...
To identify novel candidate genes for pancreatic cancer.We performed a transcriptome-wide association study (TWAS) analysis of pancreatic cancer (PC). GWAS summary data were driven from the published studies of PC, totally involving 558 542 SNPs in 1896 individuals with pancreatic cancer and 1939 ...
Transcriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and gene expression datasets to identify gene–trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes at GWAS loci, by using simulations and...