GENOME-wide association studiesPHENOTYPESGenome-wide association study has identified fruitful variants impacting heritable traits. Nevertheless, identifying critical genes underlying those significant variants has been a great task. Transcriptome-wide association study (TWAS) is an instrumental post-analysis to...
The bottom panel shows a Manhattan plot of the GWAS data before (gray) and after (blue) conditioning on the green genes. You can see that this locus goes from being genome-wide significant to non-significant after conditioning on the predicted expression of FAM109B. 蓝色和绿色基因均是通过TW...
Overview of future research direction of TWAS in CD. GWAS, genome-wide association studies; TWAS, transcriptome-wide association studies; eQTL, expression quantitative trait loci Full size image Epidemiologic studies have reported that the incidence of IBD has now leveled off in developed areas but c...
Transcriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and gene expression datasets to identify gene–trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes at GWAS loci, by using simulations and...
Root system architecture plays a crucial role in nutrient and water absorption during rice production. Genetic improvement of the rice root system requires elucidating its genetic control. Genome-wide association studies (GWASs) have identified genomic r
could result in PPD symptoms. Performing transcriptome-wide association studies (TWAS) allows for the interrogation of functional changes associated with case status. Employing TWAS, we can identify the biologically relevant changes in PPD that result from the aforementioned system disruptions, providing ...
However, current studies have found a limited number of SpA-related genes, and the genetic and pathogenic mechanisms of SpA are still unclear. Methods A tissue-specific transcriptome-wide association study (TWAS) of SpA was performed using GWAS (including 3966 SpA patients and 448,298 controls) ...
Transcriptome-wide association studies (TWASs), like genome-wide association studies (GWASs), are a useful hypothesis-free method of studying how genetic variation influences a trait. Both GWAS and TWAS have been central to the study of psychosis, having identified 145 genetic loci and 175 genes...
The study utilized the FinnGen R10 dataset, encompassing 177,901 individuals (36,601 cases and 141,300 controls), and the GTEx v8 EQTLs files to conduct single-tissue and cross-tissue transcriptome-wide association studies (TWAS). FUSION method was utilized to validate the findings in specific ...
Transcriptome-wide association studies (TWASs) aim to integrate genome-wide association studies with expression-mapping studies to identify genes with genetically predicted expression (GReX) associated with a complex trait. In the present report, we deve