Mechanism of Transcriptional Repression of E2F by the Retinoblastoma Tumor Suppressor Proteindoi:10.1016/S1097-2765(00)80310-XThe retinoblastoma tumor suppressor protein (pRB) is a transcriptional repressor, critical for normal cell cycle progression. We have undertaken studies using a highly purified ...
Our findings show that the TPL/TPR corepressor family are components of the central circadian oscillator mechanism and reinforces the role of this family as central to multiple signaling pathways in higher plants. 展开 关键词: Arabidopsis chromatin EAR domain TOC1 transcriptional repressor ...
Cvijic M and Chin K (1997) Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants. Cell Growth and Diff 8: 1243-1247. CASGoogle Scholar Egan DA and Scotto KW (1996) Glucocorticoids repress transcription of the hamster Class I P-glycoprotein promoter through an a...
PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a... PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA- dependent mechanism. Cell. 1997;90(3):459-467... AH Tang,Neufeld,P Thomas - 《Cell》 被引...
A repressor (MAT alpha 2 Product) and its operator control expression of a set of cell type specific genes in yeast. The product of the yeast MATα2 gene, α2 protein, negatively regulates expression of a class of yeast cell type specific genes, the a-specific genes. In t... AD Johns...
Mitogen-activated protein kinase (MAPK/MPK) cascades function upstream to regulate CBFs. However, the mechanism by which MPKs control CBF expression during cold stress signaling remains unknown. This study showed that the activity of MYB15, a transcriptional repressor of cold signaling, is regulated...
Thus the effect of HuR protein on EMT was described. HuR is a RBP that regulates the stability of its target mRNAs. It has been reported that HuR binds to the 3′UTR region of the Snail mRNA, inducing the stability of this transcriptional repressor of E-cadherin. In the presence of ...
Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Mol. Cell 15, 595–605 (2004). CAS PubMed Google Scholar Clouaire, T. & Stancheva, I. Methyl-CpG binding proteins: specialized transcriptional repressors or ...
protein complex named DREAM to downregulate gene expression. DREAM functions as a transcriptional repressor complex. With the advent of genome-wide experimental and bioinformatic analyses, we are now in the position to assess the wide spectrum of genes controlled through the newly defined p53–DREAM ...
Analysis of TrmBL2 binding sequences suggests that the average sequence selectivity of this DNA-architectural protein is rather low. This lack of specificity is in stark contrast with the role of TrmBL2 as a global repressor of many specific T. kodakarensis genes, a function that typically implie...