Another transcriptional regulator. ATRX. has been implicated in sex determination in humans. XY patients with mutations in this X-linked gene show sex reversal. which is associated with other phenotypes such as mental retardation (Ion, et al., 1996). The ATRX protein contains a high...
Transcriptional Regulator ATRX In subject area: Medicine and Dentistry 174 The ATRX protein is a member of the SWI/SNF DNA helicase family and consists of three domains: an N-terminal containing a plant-homeodomain-like (PHD) domain, a coiled-coil motif, and C-terminal helicase domain. ...
Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain. Nat. Genet. 17 : 146-148.Gibbons RJ, Bachoo S, Picketts DJ, Aftimos S, Asenbauer B, Bergoffen J, Berry SA, Dahl N, Fryer A, Keppler K, et al. Mutations in transcriptional regulator ...
APE1 does not only function as a regulator of the base excision repair system, but also as a redox regulator [57]. The GGAA-duplication is contained in the regulatory region of the head-head configured ACO2/PHF5A genes [12]. The ACO2 encodes aconitase that functions in the TCA cycle ...
Metrics Abstract Transcriptional coregulators contribute to several processes involving nuclear receptor transcriptional regulation. The transcriptional coregulator androgen receptor-interacting protein 4 (ARIP4) interacts with nuclear receptors and regulates their transcriptional activity. In this study, we identif...
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev. 2006;20:966–76. 47. Tiefenbach J, Novac N, Ducasse M, Eck M, Melchior F, Heinzel T. SUMOylation of the corepressor N-CoR modulates its...
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev. 2006;20:966–76. 47. Tiefenbach J, Novac N, Ducasse M, Eck M, Melchior F, Heinzel T. SUMOylation of the corepressor N-CoR modulates its...
1997. Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain. Nat. Genet. 17:146-148.Gibbons RJ, Bachoo S, Picketts DJ, Aftimos S, Asenbauer B, Bergoffen J, et al. Mutations in transcriptional regulator ATRX establish the functional signifi- ...
We have identified the PHD-like zinc finger of the ATRX domain as a main repression motif of DNMT3L, through which DNMT3L recruits the HDAC activity needed for transcriptional silencing. Furthermore, we show that DNMT3L protein contains an active nuclear localisation signal at amino acids 156鈥...
ATRX Transcriptional regulator ATRX + + x IRF2BP1 Interferon regulatory factor 2-binding protein 1 + x IRF2BP2 Interferon regulatory factor 2-binding protein 2 + x NFIL3 Nuclear factor interleukin-3-regulated protein + RREB1 Ras-responsive element-binding protein 1 + TMPO Lamina-associated po...