Overall, we propose a negative regulation of Anabaena MT by an α5 SmtB/ArsR metalloregulator AzuR.doi:10.3389/fmicb.2021.782363Divya, T. V.Acharya, CelinFrontiers Media SAFrontiers in Microbiology
[Objective] We revealed the function of the ArsR(Arsenical resistance regulator) family regulator XanR3 in xantholipin biosynthetic gene cluster. [Methods] Genetically, the xanR3 disrupted mutant CGF03 andcomplementary strain CGF06 were constructed by conjugation between S. flavogriseus SIIA-A02191 ...
Since dimerization is essential for DNA binding and repression by the ArsR family proteins we have generated the dimeric model of SoxR that enables us to predict the DNA binding residues of the protein as well as the interaction of SoxR with the predicted promoter region of sox gene cluster. ...
Two novel TFs from the ArsR family analyzed in theLactobacillaceaeare distantly related to the CzcR regulator of cobalt-zinc-cadmium resistance fromPseudomonas aeruginosa[37]. The reconstructed CzcR1 and CzcR2 regulons were predicted to control different sets of genes involved in heavy metal resistanc...
Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus. Microbiology. 2008;154(Pt 3):905–14. Article CAS PubMed Google Scholar Pompeani AJ, Irgon JJ, Berger MF, Bulyk ML, Wingreen NS, Bassler BL. The Vibrio harveyi ...
We identified Ms4022 (MSMEG_4022) as a novel TetR family regulator that activates the expression of seven transport-related genes and affects drug resistance in M. smegmatis. Overexpression of Ms4022 inhibited M. smegmatis growth and enhanced mycobacterial resistance to the anti-tuberculosis drug ...
As an exception, Mycobacterium tuberculosis has two Ni(II)/Co(II) sensors—NmtR and KmtR—from the ArsR/SmtB regulator family that both regulate expression of efflux transporters, albeit with different metal sensitivities (59). Why M. tuberculosis has two similar regulators is not clear, but ...
[26]proteins. Alternatively, the regulator'sDNA bindingaffinity/specificity can be altered by association with a ligand molecule; in these cases the concentration of both regulator protein and ligand may be considered inputs. In addition to classical examples of inducible promoters controlled by ...
Although SoxR proteins do not contain the conserved metal-binding box, ELCVCDL, but there are a number of well conserved residues present throughout the sequence that are previously identified in the known ArsR family proteins. We employed homology modeling to construct the three-dimensional ...
Disruption of the rexT gene (alr1867), encoding a transcriptional regulator of the ArsR family, resulted in increased expression of trxA2. RexT bound to the region downstream of the transcription initiation site of trxA2. The DNA binding activity of RexT was impaired by H2O2 through the ...