Transcriptional regulator CarDIn vitro and mouse studies suggest that inhibiting CarD could help treat Mycobacterium tuberculosis infection. Further details on the research, next steps and licensing status are discussed in the article.Science-Business eXchange...
CarD is an essential global transcription regulator fromMycobacterium tuberculosis (Mtb)that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex. Available crystal structures have captured two distinct, monomeric and domain-swapped homodimeric, oligomeric states of...
In conclusion we have identified and characterized the function of a new member of the human CARD-containing family of proteins. The CARD domain of CARD-8 has a high degree of homology to the CARD domain of caspase-1 and can bind to caspase-1 and its related proteins pseudo-ICE and ICEBE...
In this context, it is worth noting that the steroid hormone coactivator-1 also belongs to the bHLH-PAS family and that it and Met have the LXXLL motif, which in vertebrate transcriptional activators is needed for binding to nuclear receptors. The identification of JH response elements in JH ...
(NLR) family member NLRC5 (NLR family, CARD domain containing protein 5) in the transcriptional regulation of major histocompatibility complex (MHC) class ... ST Chelbi - 《Advances in Immunology》 被引量: 2发表: 2017年 A Me'nage à trois: NLRC5, immunity, and metabolism The nucleotide-bi...
Legionella pneumophila (Lp) flagellin activates signaling pathways in murine macrophages that control Lp replication. Nucleotide-binding oligomerization domain (NOD) containing-like receptor (NLR) family, caspase recruitment domain (CARD) containing 4 (N
At the heart of this complex machinery is a conserved family of cysteine proteases, the caspases, which are produced in cells as catalytically inactive zymogenes and require proteolytic activation during apoptosis (Cohen, 1997). Caspases are divided into two classes depending on their place in the...
Furthermore, Tgfb2, Bmp6, inhibitor of DNA binding 3 (Id3) and SMAD family member 6 (Smad6) were induced in the endocardial layers (Fig. 5c, Supplemental Fig. 4, Supplemental Table 1). Taken together, both Tbx2 and Tbx3 in myocardium are sufficient to induce cushion formation and ...
Discovery of Disease-Causing CARD14 Mutations Psoriasis susceptibility locus 2 (PSORS2) was mapped in 1994 to human chromosomal region 17q25-qter in a single large European family (PS1) (Tomfohrde et al.1994). Affected members had plaque psoriasis and 30% also developed psoriatic arthritis. A...
Mice deficient for the stress-induced transcriptional regulator p8 have a decreased metalloprotease 9 induction and cardiac fibrosis after transverseConstriction, AGoruppi, SGeorgescu, SIovanna, JAronowitz, MPatten, RKyriakis, J