To be consistent with the sign of the metric we used 1–Spearman correlation coefficient as the second measure of transcriptional noise. (5)为了统计评估每种细胞类型中转录噪声与年龄之间的关联,我们使用了Wilcoxon的秩和检验。随后使用R函数p.adjust()实现的Bonferroni-Hochberg方法对p值进行多次测试的校正。
你所说的 Transcriptional Noise,就是指在细胞内部的转录过程中,转录效率、转录频率等参数不稳定,围绕一定的值上下波动的现象.如果把“转录”这一过程写成由DNA和RNAP催化的,从 NTP 到 mRNA 的化学反应方程式的话,这一宏观方程所描述的过程就是信号 signal,而由于上述波动导致的不确定性就是噪声 noise 你可以去...
你所说的 Transcriptional Noise,就是指在细胞内部的转录过程中,转录效率、转录频率等参数不稳定,围绕一定的值上下波动的现象.如果把“转录”这一过程写成由DNA和RNAP催化的,从 NTP 到 mRNA 的化学反应方程式的话,这一宏观方程所描述的过程就是信号 signal,而由于上述波动导致的不确定性就是噪声 noise 你可以去...
网络转录噪声 网络释义 1. 转录噪声 ...士表示,最初人们普遍认为lncRNA仅仅是基因的“转录噪声(transcriptional noise)”,然后近年来越来越多有功能的非编码R… www.ebiotrade.com|基于14个网页
Cell CycleSubstantial variability in the transcriptional activity of particular genes is frequently observed among genetically identical single cells in a cell population. This 'noise' is often attributed to a stochastic transcriptional bursting activity that is intrinsic to the genes being studied. ...
This noise determines the heterogeneity of gene expression in different cells of the organism and contributes to differentiation and phenotypic differences. noise; Blake et al 2003 Nature [Lond] 422:633.Chapter Metrics Citations Other actions Reprints and Permissions Export citation About this ...
Cell CycleBall DA, Adames NR, Reischmann N, Barik D, Franck CT, Tyson JJ, et al. Measurement and modeling of transcriptional noise in the cell cycle regulatory network . Cell Cycle . 2013; 12 ( 19 ):3203–18. doi: 10.4161/cc.26257 ; PubMed Central PMCID: PMCPMC3865016....
(1)) is a degenerate case that arises from the limit of no noise and fast mean-reversion, and the mixture model arises from the limit of slow transcription rate variation. We will see later that the popular bursting model of RNA production, which describes intermittent production of multiple ...
The Evolution of Controlled Multitasked Gene Networks: The Role of Introns and Other Noncoding RNAs in the Development of Complex Organisms Eukaryotic phenotypic diversity arises from multitasking of a core proteome of limited size. Multitasking is routine in computers, as well as in other soph.....
Another potential indicator of transcriptional noise is the increased formation of circular RNAs (circRNAs)39,40, that is, of back-spliced transcripts with covalently linked 3′ and 5′ ends41. Increased speed of Pol II has previously been associated with increased abundance of circRNA42. Thus, ...