What are transcription factors? This lesson will define transcription factors, discuss their functions, and their unique classes.
Transcription factor, molecule that controls the activity of a gene by determining whether the gene’s DNA is transcribed into RNA. Transcription factors control when, where, and how efficiently RNA polymerases, which catalyze the reactions that synthesi
A five-transcription-factors based predictive model for colon cancer prognosis has been developed by using TCGA colon cancer patient data. Five transcription factors identified for the predictive model is HOXC9, ZNF556, HEYL, HOXC4 and HOXC6. The prediction power of the model is validated with ...
1.3Transcription factors and cofactors 1.3.1General transcription factors and their cofactors Gene transcriptionis initiated with core promoters, where general transcription factors form a complex calledtranscription preinitiation complex(PIC), together withRNApolymerase II to promote basal level of ...
Many transcription factors regulate gene expression in a lineage- and process-specific manner, despite being expressed in several cell types. Here, the authors show that the Hox transcription factor Ubx has lineage-specific interactomes, which contribute to its cell context-dependent functions. Julie ...
R. Targeting transcription factors in cancer. Trends Cancer 1, 53–65 (2015). Article PubMed PubMed Central Google Scholar Burris, T. P. et al. Nuclear receptors and their selective pharmacologic modulators. Pharmacol. Rev. 65, 710–778 (2013). Article PubMed CAS Google Scholar de The...
1.Analysis of abnormal transcription factors and pathways from gastric cancer chips;胃癌芯片数据中异常转录因子推断与信号通路分析 2.Liver-enriched transcription factors and their regulatory network of liver:research advances;肝组织中肝富集转录因子及其调控网络的研究进展 3.Expression,purification of human tran...
Although it is likely that many of these factors and their cognate histone markers are involved in Ig gene transcriptional regulation, their actual functions and mechanisms of action in the regulation of Ig genes in B cells remain mostly undetermined. The cofactors that act more directly include ...
The genetics of the E2F family of transcription fac- tors: shared functions and unique roles. Biochim Biophys Acta 2002;1602(2):131-50.DeGregori, J. 2002. The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim. Biophys. Acta 1602:131-150....
Innate lymphoid cells (ILCs) play important functions in immunity and tissue homeostasis, but their development is poorly understood. Through the use of single-cell approaches, we examined the transcriptional and functional heterogeneity of ILC progenito