transcription factorstransdifferentiationgastric mucosaThe analysis of intestinal differentiation transcription factor CDX2 in the gastric mucosa biopsies has been carried out. It was established that CDX2 by its own promoter activation pathway can obtain intestinal phenotype for gastric mucosa cells. The ...
Studying nucleosome dynamics in promoter regions is crucial for understanding gene regulation. Nucleosomes regulate gene expression by sterically occluding transcription factors (TFs) and other non–histone proteins accessing genomic DNA. How the binding
Abstract Plant responses to multiple stresses play significant role in identifying the novel candidate genes regulating the complex molecular mechanisms under abiotic and biotic stress conditions. The vital role of transcription factors for controlling stress regulatory network has been elucidated in several ...
Using different sets of experiments we infer different roles of regulation. Using experiments {e1, e2, e3}, for example, our qualitative system will have three constraints and not all valuations of variables S BA and S CA satisfy this system according to the sign algebra rules. As we obtain...
Blimp-1 promoted the migration and adhesion of plasmablasts. It directly repressed genes encoding several transcription factors and Aicda (which encodes the cytidine deaminase AID) and thus silenced B cell–specific gene expression, antigen presentation and class-switch recombination in plasmablasts. It...
The promoter region of the human Podxl gene has been cloned and its structure and function were analyzed. The primary DNA sequence is rich in G+C and is devoid of TATA or CAAT boxes. The sequence contains recognition sites for several putative transcription factors; however, the basic promoter...
During the search for regulation targets of uncharacterized transcription factors by Genomic SELEX screening, we found that the hitherto uncharacterized YdcN regulates a set of genes involved in the utilization of sulfur, including the generation of sulfate and its reduction, the synthesis of cysteine,...
(see Fig.2). Then, the ambiguity of the regulatory role can be attributed to three factors: (1) a complex mechanism of regulation, the role of the interaction depends on the state of the system; (2) a missing interaction in the model; (3) an error in the experimental source. This ...
using the human embryonic kidney (HEK293T) cells, which are useful for evaluation of the transactivation activity of hematopoietic cell-specific transcription factors. Luciferase activity driven by the shortest promoter (−136/+71) was significantly augmented with ectopic PU.1 to a similar ...
The zinc finger transcription factor gene, CASZ1/Castor (Castor zinc finger 1), initially identified in Drosophila, plays a critical role in neural, cardiac, and cardiovascular development, exerting a complex, multifaceted influence on cell fate and tiss