Research Highlights20 Jul 2023 Nature Reviews Molecular Cell Biology Volume: 24, P: 604 Measuring the impact of chromatin context on transcription factor binding affinities We have designed a method, binding affinities to native chromatin by sequencing (BANC-seq), to determine the transcription fac...
The Psu protein of phage satellite P4 inhibits transcription termination factor ρ by forced hyper-oligomerization Many bacteriophages can modulate host transcription. Here, the authors uncover the anti-termination mechanism of phage satellite P4 protein, Psu. Psu dimers clamp two open rings of the ...
Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, et al. (2012) The transcription factor encyclopedia. Genome biology 13: R24. doi: 10.1186/gb-2012-13-3-r24 PMID: 22458515D. Yusuf, S.L. Butland, M.I. Swanson, E. Bolotin, A. Ticoll, W.A. Cheung, X.Y. Zhang...
In subject area: Biochemistry, Genetics and Molecular Biology Positive transcription elongation factor-b (p-TEFb): a cyclin-dependent kinase containing the catalytic subunit CDK9 and one of the T1, T2, or K cyclin subunits. From: Trends in Biochemical Sciences, 2015 ...
Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a simple protocol for detection of open chromatin. Computational footprinting, the search for regions with depletion of cleavage events due to transcription factor binding, is poorly u
Transcription termination factor (Rho) plays a key role in the transcription termination in bacteria. It is a homo-hexameric RNA-dependent ATPase that binds to nascent RNA by recognizing therutsite (rho utilization site; a C-rich unstructured stretch of the nascent RNA). It utilizes...
The myeloblastosis (MYB) transcription factor (TF) family is one of the largest and most important TF families in plants, playing an important role in a life cycle and abiotic stress. In this study, 268 Avena sativa MYB (AsMYB) TFs from Avena sativa were
Here we show that the aromatic character of the activation domain of the androgen receptor, a therapeutic target for castration-resistant prostate cancer, is key for its activity as transcription factor, allowing it to translocate to the nucleus and partition into transcriptional condensates upon ...
Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such observations requires quantitative studies of TF dosage effects at trait-relevant ranges, largely lacking so far. TFs play central roles in both normal-rang...
Transcription factor genes comprise a substantial fraction of all eukaryotic genomes. On the basis of the type of DNA-binding domain that they encode, the majority of transcription factor genes can be grouped into a handful of different, often large, families. Functional redundancy is not unusual ...