Transcription factor, molecule that controls the activity of a gene by determining whether the gene’s DNA is transcribed into RNA. Transcription factors control when, where, and how efficiently RNA polymerases, which catalyze the reactions that synthesi
Here the authors used single-molecule imaging and manipulation to study the mechanical effects of transcription factor Sox2 co-condensation with DNA and chromatin. They found that Sox2 condensates exert a high level of mechanical stress on DNA, but this stress is dramatically attenuated by nucleosome...
typically respond to signals from within the cell that indicate whether transcription is required. In many human genes, several transcription factors may be needed before transcription can proceed efficiently. A transcription factor can cause either repression or activation of gene expression in eukaryotes...
Gene expression in Escherichia coli is controlled by well-established mechanisms that activate or repress transcription. Here, we identify CedA as an unconventional transcription factor specifically associated with the RNA polymerase (RNAP) σ70 holoenzy
Fig. 2.The interactions of Jun and Fos proteins. The transcription factor AP-1 is formed by dimerization of Jun proteins (c-Jun, JunB and JunD) or heterodimerization of a Jun protein with a Fos protein (c-Fos, FosB, Fra-1 and Fra-2). AP-1 binds primarily to the 12-O-tetradecanoylp...
A transcription factor atlas of directed differentiation Cell, Volume 187, Issue 12, 6 June 2024, Pages 3161 Julia Joung, Sai Ma, Tristan Tay, Kathryn R. Geiger-Schuller, Paul C. Kirchgatterer, Vanessa K. Verdine, Baolin Guo, Mario A. Arias-Garcia, William E. Allen, Ankita Singh, Olena...
This study focuses on patterns of transcription factor expression in the earliest stages of T cell differentiation and their relationship to developmental potentials at the single-cell level using single-molecule fluorescence in situ hybridization and RNA sequencing for high-sensitivity quantitation of the...
et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113, 643–655 (2003). Article CAS PubMed Google Scholar Smith, A. G. et al. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336, 688...
Transcription factor IID (TFIID), like SAGA, is a multi-subunit co-factor forRNApolymerase II transcription that also contains HAT activity. However, SAGA andTFIIDmake complementary contributions to gene expression in yeast[121]. Whereas TFIID is involved in the regulation of the vast majority...
a protein calledTranscription Factor IID(TFIID) onto a promoter, followed by the recruitment of a group of TF proteins calledgeneral transcription factors(GTFs). These promoter-bound GTFs then recruit RNA polymerase II to form a preinitiation complex. Eukaryotic promoters often haveDNA seque...