Transcription factor, molecule that controls the activity of a gene by determining whether the gene’s DNA is transcribed into RNA. Transcription factors control when, where, and how efficiently RNA polymerases, which catalyze the reactions that synthesi
Multi-level and lineage-specific interactomes of the Hox transcription factor Ubx contribute to its functional specificity Many transcription factors regulate gene expression in a lineage- and process-specific manner, despite being expressed in several cell types. Here, the authors show that the Hox...
Transcription in eukaryotes is more complicated than in prokaryotes. First, the RNA polymerase of higher organisms is a more complicated enzyme than the relatively simple five-subunit enzyme of prokaryotes. In addition, there are many more accessory factors that help to control theefficiencyof the in...
AlexeyUshmorov,ThomasWirth, inSeminars in Cancer Biology, 2018 Abstract FOX O family transcription factors are important for differentiation and function of multiple cell types. In B lymphocytes they play a critical role. The activity of FOXOs is directly regulated both by signaling from B cell...
coliσ factors (Extended Data Fig. 3) reveals a high degree of similarity between σ70 and σS in region 1.2, while σ32 appears more distant, and other σ factors have no apparent similarity. A structural alignment (Extended Data Fig. 4) mirrors the sequence comparison, implying that CedA...
AlessandroBisello,Peter A.Friedman, inPrinciples of Bone Biology (Third Edition), 2008 Transcription Factors A major effect ofPTHandPTHrPin osteoblasts is directed to modulating the expression and/or function of a number of transcription factors known to be important inbone metabolism. Among these, ...
General transcription factors are proteins that help to position Pol II correctly on the promoter, the region of a gene where transcription is initiated, pull aside the two strands of DNA and then move Pol II into the elongation mode.
AlessandroBisello,Peter A.Friedman, inPrinciples of Bone Biology (Third Edition), 2008 Transcription Factors A major effect ofPTHandPTHrPin osteoblasts is directed to modulating the expression and/or function of a number of transcription factors known to be important inbone metabolism. Among the...
Transcription factors (TFs) are crucial epigenetic regulators, which enable cells to dynamically adjust gene expression in response to environmental signals. Computational procedures like digital genomic footprinting on chromatin accessibility assays suc
A total of 914 transcription factors were identified in theA. leiigenome. Transcription factor superfamily members were categorized into 45 different classes according to the functional domain characteristics (Supplementary Table8). After the “zinc finger” transcription factor type, “homeobox” was the...