Activating transcription factor 4 (ATF4) belongs to the ATF/CREB (activating transcription factor/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip) transcription factors, which have the consensus binding site cAMP responsive element (CRE). ATF4 has numerous ...
The ATF4 gene encodes a transcription factor which was initially identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. 序列 请咨询我们客服或者请查看品牌官方网站 来源宿主 大肠杆菌中重组表达. 溶解建议 提供的重组人活化...
2012. Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties. Arch Virol 157:63-74.Caselli E, Benedetti S, Grigolato J, Caruso A, Di Luca D. 2012. Ac- tivating transcription factor 4 (ATF4) ...
Activating transcription factor 4 (ATF4), a key mediator of the ISR, and has been reported to induce the expression of genes involved in cellular homeostasis. However, during prolonged activation ATF4 can also induce the expression of pro-death target genes. Therefore, in the present study, we...
Activating transcription factor 4 (ATF4) is a regulator of the unfolded protein response and integrated stress response (ISR), which are known as adaptive mechanisms to endoplasmic reticulum (ER) stress. Previous reports demonstrated that dysregulation of the ISR showed development of severe diabetes....
By using BTG-1 promoter haboring reporter gene and siRNA, activating transcription factor 4 (ATF4) was identified as an essential transcription factor for SAAD-mediated BTG-1 induction. Knock out of BTG-1 gene by CRISPR/Cas9 system decreased the cytotoxicity by SAAD. Furthermore, BTG-1 ...
Their nucleotide sequences revealed that they encode activating transcription factor 4 (ATF4). A full-length cDNA of porcine ATF4 was obtained by the polymerase chain reaction, and its deduced amino acid sequence showed 88 and 83% identity to human and mouse ATF4, respectively. Reverse ...
Furthermore, it has been indicated that two UPR pathways, PERK-eukaryotic initiation factor 2α (eIF2α)-ATF4 and IRE-1-X-box binding protein 1 (XBP1) pathways, are involved in the stimulation ofde novolipogenesis in the liver (13). The PERK-eIF-2α-ATF4 pathway, which activates transc...
(2003). Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4). FEBS Lett. 547, 15-19.De Angelis, R, et al., Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4). FEBS Lett, 2003. ...
Here, we find out a novel relationship between the circadian transcription factor Clock and drug resistance. Clock drives the periodical expression of many genes that regulate hormone release, cell division, sleep-awake cycle and tumor growth. We demonstrate that ATF4 is a direct target of Clock,...