Activating transcription factor 4ATF4HypoxiaAnoxiaCancerActivating transcription factor 4 (ATF4) belongs to the ATF/CREB (activating transcription factor/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip) transcription factors, which have the consensus binding site ...
Activating transcription factor 4 (ATF4) is a fundamental basic region/leucine zipper transcription factor, responds to various stress signals, and plays crucial roles in normal metabolic and stress response processes. Although its functions in human health and disease are not completely understood, ...
Activating transcription factor 4 (ATF4) is a member of a family of DNA-binding proteins which includes the AP-1 family of transcription factors, cAMP-response element binding proteins and CREB-like proteins. The ATF4 gene encodes a transcription factor which was initially identified as a widely ...
Activating transcription factor 4 (ATF4), a key mediator of the ISR, and has been reported to induce the expression of genes involved in cellular homeostasis. However, during prolonged activation ATF4 can also induce the expression of pro-death target genes. Therefore, in the present study, we...
By using BTG-1 promoter haboring reporter gene and siRNA, activating transcription factor 4 (ATF4) was identified as an essential transcription factor for SAAD-mediated BTG-1 induction. Knock out of BTG-1 gene by CRISPR/Cas9 system decreased the cytotoxicity by SAAD. Furthermore, BTG-1 ...
Activating Transcription Factor 4 is a stress induced transcription factor that can regulate a multitude of different immune cell responses. The regulation of immunity via ATF4 can be indirect by initiating inflammation that will secrete a cascade of cytokine directed immune responses. In contrast, ATF4...
Their nucleotide sequences revealed that they encode activating transcription factor 4 (ATF4). A full-length cDNA of porcine ATF4 was obtained by the polymerase chain reaction, and its deduced amino acid sequence showed 88 and 83% identity to human and mouse ATF4, respectively. Reverse ...
(D) TG content was decreased in ATF4-deficient HepG2 cells cultured with 20 mM fructose. **P<0.01, vs. the N group, #P<0.05 and ##P<0.01 vs. the F group. ATF4, activating transcription factor-4; CHOP, C/EBP homologous protein; siRNA, small interfering RNA; TG, triglyceride; N, ...
activating transcription factor 4 (ATF4)Fibroblast growth factor 21 (FGF21)endoplasmic reticulum (ER) stresstranscriptionamino acid response element (AARE)Ryuto MaruyamaDepartment of Applied Biological ChemistryMakoto ShimizuDepartment of Applied Biological ChemistryJuan Li...
化学名:ATF4, ID (ATF4, CREB2, TXREB, Cyclic AMP-dependent transcription factor ATF-4, Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, Tax-responsive enhancer element-binding protein 67) (MaxLight 405) 英語化学名:ATF4, ID (ATF4...