The ATF4 gene encodes a transcription factor which was initially identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. 序列 请咨询我们客服或者请查看品牌官方网站 来源宿主 大肠杆菌中重组表达. 溶解建议 提供的重组人活化...
Activating transcription factor 4ATF4HypoxiaAnoxiaCancerActivating transcription factor 4 (ATF4) belongs to the ATF/CREB (activating transcription factor/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip) transcription factors, which have the consensus binding site ...
Activating transcription factor 4 (ATF4) is a fundamental basic region/leucine zipper transcription factor, responds to various stress signals, and plays crucial roles in normal metabolic and stress response processes. Although its functions in human health and disease are not completely understood, ...
Activating transcription factor 4 (ATF4), a key mediator of the ISR, and has been reported to induce the expression of genes involved in cellular homeostasis. However, during prolonged activation ATF4 can also induce the expression of pro-death target genes. Therefore, in the present study, we...
By using BTG-1 promoter haboring reporter gene and siRNA, activating transcription factor 4 (ATF4) was identified as an essential transcription factor for SAAD-mediated BTG-1 induction. Knock out of BTG-1 gene by CRISPR/Cas9 system decreased the cytotoxicity by SAAD. Furthermore, BTG-1 ...
Activating transcription factor 4 (ATF4) is a regulator of the unfolded protein response and integrated stress response (ISR), which are known as adaptive mechanisms to endoplasmic reticulum (ER) stress. Previous reports demonstrated that dysregulation of the ISR showed development of severe diabetes....
Their nucleotide sequences revealed that they encode activating transcription factor 4 (ATF4). A full-length cDNA of porcine ATF4 was obtained by the polymerase chain reaction, and its deduced amino acid sequence showed 88 and 83% identity to human and mouse ATF4, respectively. Reverse ...
Activating transcription factor 4 (ATF4) belongs to the basic leucine zipper (bZIP) transcription factor superfamily and is a master regulator that plays a crucial role in the adaptation to stresses [1]. ATF4 participates in the integrated stress response (ISR), involved in amino acid metabolism,...
carbohydrate-responsive element-binding protein; SCD-1, stearoyl-CoA desaturase 1; FAS, fatty acid synthase; ACC, acetyl-CoA carboxylase; ATF4, activating transcription factor-4; siRNA, small interfering RNA; N, normal medium group; F, fructose group; F+NC, fructose + transfection reagents group...
(2003). Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4). FEBS Lett 547: 15-19.De Angelis,R., Iezzi,S., Bruno,T., Corbi,N., Di Padova,M., Floridi,A., Fanciulli,M. and Passananti,C. (2003) Functional inter- action of the...