主要集中在转录因子活性(transcription factor activity) 和序列特异性DNA 结合(sequence-specific DNA binding)相关基因 … ydpaper.org|基于 1 个网页 2. 录因子活性 录因子活性(transcription factor activity)相关基因群,表明大部分基因的功能都与转录因子活性有关。
Functional sequestration of transcription factor activity by repetitive DNA. 来自 国家科技图书文献中心 喜欢 0 阅读量: 20 作者:X Liu,W Bo,J Szary,EM Kofoed,F Schaufele 摘要: Higher eukaryote genomes contain repetitive DNAs, often concentrated in transcriptionally inactive heterochromatin. Although ...
modelling transcription factor activitytime course gene expressionODE formulationODE and differential operatordiscretisation schemeHidden Variable Dynamic Modelling (HVDMMarkov chain Monte Carlo (MCMCintermediate point estimationThis chapter contains sections titleddoi:10.1002/9781119970606.ch22...
从GO数据库里找:Transcription factors were identified using GO terms transcription factor activity (GO:0000989), and regulation of transcription, DNA dependent (GO:0006355). 最终合并三者得到一个完整的TF list 研究可以做得很浅,查查genecard数据库,从数据库里找找motif,用工具跑跑target gene,构建一下基因...
Transcription factor activity at genomic loci was assayed using the Dual-Glo Luciferase Assay system (Promega). Mouse embryonic stem cells were seeded at a density of 1 × 105 cells cm−2 on 24-well plates that had been pre-coated with gelatin. For feeder-free culture conditions,...
Changes in cell fate are characterized by changes in gene transcription, dictated by (master) transcription factor activity. SOX9 is the master transcription factor for chondrocyte development. Its impaired function is implicated in osteoarthritis and growth disorders, such as dwarfism. However, the ...
Notably, the advent of in-depth sequencing studies has elucidated alternative transcription factor activity among closely related islet cell subtypes2,3 and additionally, uncovered numerous examples of heterogeneity within healthy β-cells4. It has long been recognized that differences in cellular ...
The activity of a transcription factor is often regulated by (de)phosphorylation, which may affect different functions, e.g. nuclear localization, DNA binding and trans-activation. Ligand binding is another mode of transcription-factor activation. It is typical for the large superfamily of nuclear ...
Transcription factor, molecule that controls the activity of a gene by determining whether the gene’s DNA is transcribed into RNA. Transcription factors control when, where, and how efficiently RNA polymerases, which catalyze the reactions that synthesi
Neuronal activity also activates transcription by relocalizing latent transcription factors from the cytoplasm to the nucleus. NFAT (nuclear factor of activated T cells) and NF-κB (nuclear factor-κB) are expressed in the nervous system and relocate to the nucleus in response to neuronal stimuli....