However, the accessible laboratory findings for CREB activity of the previous research still not strong enough for continuing to the clinical trial yet.doi:10.1016/j.bcp.2021.114531Khaled BenchoulaIshwar S ParharPriya MadhavanWong Eng HwaBiochemical Pharmacology...
1991. Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB. Mol. Cell. Biol. 11:1306-1312... GA Gonzalez,P, Menzel,J, Leonard,... - 《Molecular & Cellular Biology》 被引量: 994发表: 1991年 Coupling of Hormonal Stimulation and T...
safety and activity of sintilimab in patients with relapsed or refractory classical hodgkin lymphoma (orient-1) a multicentre, single-arm, phase 2 热度: Transgenicsongbirdswithsuppressedorenhanced activityofCREBtranscriptionfactor KentaroAbe a,b,1 ...
(CBP)is crucial in mediating the transcriptional activity of CREB.In nervous system,in addition to playing a role in neurotransmitter-induced gene transcription,CREB may take part in mediating neurotrophin signals that ultimately lead to such cellular responses as proliferation, differentiation and ...
Previously, we and others showed within the lateral amygdala (LA), a region critical for auditory conditioned fear, eligible neurons compete against one other for allocation to an engram. Neurons with relatively higher function of the transcription factor CREB were more likely to be allocated to ...
(1998) Occurrence of a transcription factor, cAMP response element-binding protein (CREB), in the postsynaptic sites of the brain. Brain Res. Mol. Brain Res. 61, 69-77.Suzuki, T, Usuda, N., Ishiguro, H., Mitake, S., Nagatsu, T., & Okumura-Noji, K. (1998). Occurrence of a ...
Both ATF/CRE motifs overlap binding sequences for the multifunctional YY1 transcription factor, which has previously been shown to be nuclear matrix associated. Subnuclear fractionation reveals that there are two ATF1 isoforms which appear to differ with respect to DNA binding activity and partition ...
CREB亚家族共有三个成员,除CREB外,还有cAMP响应元件调节蛋白(cAMP response element modulatory protein, CREM)和激活转录因子-1(activated transcription factor, ATF-1)。CREB共有341个氨基酸残基,从N端到C端几个主要的结构域为:Q1、KID、Q2、碱性区、亮氨酸拉链模体[1]。激酶诱导结构域(kinase induced domain, ...
The glutamine-rich Q2 domain, which interacts with the general transcription factor TAFII130/135, is sufficient for the recruitment of a functional RNA polymerase II complex and allows basal transcriptional activity. The kinase-inducible domain, however, mediates signal-induced activation of CREB-...
We show that overexpression of the transcription factors, CREB, -1, , and dramatically increases promoter activity in F9-differentiated . We further show that the coactivators and up-regulate the promoter when CREB and -1 are expressed in conjunction with kinases that phosphorylate CREB on serine ...