In this review, we present versatile regulatory modes of CREB family transcription factors and discuss their functional consequences.doi:10.3389/fnmol.2024.1408949Md Arifur Rahman ChowdhuryMd Mazedul HaqJeong Hwan LeeSangyun JeongFrontiers in Molecular Neuroscience...
Together with the previous studies demonstrating the importance of BDNF in synaptic function, these findings suggest that BDNF is a critical target of the CREB family of transcription factors and that this target may mediate the CREB family's effects on synaptic function. Results Ca2+ Influx ...
Atf3 is a stress-inducible gene encoding a member of the ATF/CREB family of transcription factors. Atf3 is a downstream target of Atf4, NFκB, and JNK [129]. Atf3 is increased in response to the ER stress inducer thapsigargin [137] and multiple β-cell stressors including IL-1β alone...
ΔFosB (a truncated form of FosB) and CREB (cAMP response element binding protein) are transcription factors induced in the brain's reward pathways after chronic exposure to drugs of abuse. However, their mechanisms of action and the genes they regulate
Transcription factors in long-term memory and synaptic plasticity [ J] . Physiol Rev, 2009, 89(1) : 121-145. [ 2 ] Lonze BE, Ginty DD. Function and regulation of CREB family transcription factors in the nervous system [ J] . Neuron, 2002, 35(4) : 605-623. [ 3 ] Morè...
Cyclic AMP-responsive element-binding protein 3-like protein 1(CREB3L1) belongs to a family of transcription factors that are synthesized as membrane-bound precursors in the endoplasmic reticulum (ER) and then transported to the Golgi where they are activated through regulated intramembrane proteolysis...
CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neu- rons[J]. J Neurosci, 2020,40(7):1405-1426. [23] LIU W, GE T, LENG Y, et al. The role of neural plasticity in depression: from hippocampus to prefrontal cortex[J]. Neural Plast,...
The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene familyAnti-phospho-CREB-1 (Thr100)抗体include CREB-1, CREB-2, ATF-1,ATF-2,ATF-3and ATF-...
The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE)Anti-phospho-CREB-1(Ser133)抗体palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1,ATF-2,ATF-3and ATF-4...
Cyclic AMP Response Element Binding (CREB) protein is a member of the CREB/ATF (Activating Transcription Factor) family of transcription factors playing an important role in the nuclear responses to a variety of external signals that lead to proliferation, differentiation, apoptosis and survival. Othe...