1. lncRNA TPRG1-AS1抑制HASMCs迁移 数据分析表明,TPRG1-AS1在人类动脉组织(包括主动脉和冠状动脉)表达,并在动脉粥样硬化斑块中显著增加;PDGF-BB(一种生长因子,促进VSMC表型转换)处理的HASMCs中,TPRG1-AS1表达发生下调,提示TPRG1-AS1可能参与HASMCs表型转换。cDNA末端快速扩增和Sanger测序获知TPRG1-AS1全长127...
TPRG1-AS1 induced tumour suppressor RNA-binding motif protein 24 (RBM24), suppressing tumour growth by activating apoptotic tumour cell death. In addition, we report that TPRG1-AS1 acts as a competing endogenous RNA (ceRNA) for RBM24, sponging miR-4691-5p and miR-3659 to interfere with ...
The TPRG1-AS1-has-miR-363-3p-MYO1B regulatory network was distinguished by analysis for expression, survival, and correlation. Our finding adds to the understanding of the molecular mechanism of HNSC and comes up with new targets for the treating of HNSC. Results High expression of CCND1 in...
The potential of TPRG1-AS1 in predicting the occurrence of MACE was assessed by logistic regression analysis.Results Significant upregulation of TPRG1-AS1 was observed in ACS patients, which served as a risk factor for ACS and distinguish between ACS patients and the normal group. ...
doi:10.1007/s12672-024-01654-1Cervical squamous cell carcinomaTPRG1-AS1miR-590-3pPrognosisCervical squamous cell carcinoma (CSCC) has a poor prognosis due to persistent HPV infection. LncRNA TPRG1-AS1 is linked to regulating the development of many cancers, so the regulatory mechanism and ...
本发明提供了一种冠心病相关长链非编码RNA TPRG1AS1及其结合蛋白MYH9的应用.具体而言,本发明提供了长链非编码RNA TPRG1AS1在制备调控平滑肌细胞迁移的试剂中的应用,还提供了长链非编码RNA TPRG1AS1在制备抑制血管新内膜形成的制剂中的应用.本发明还提供了长链非编码RNA TPRG1AS1在制备与MYH9蛋白相互作用的制剂中的...
In conclusion, we found a CCND1-related ceRNA network and identified the novel TPRG1-AS1-hsa-miR-363-3p-MYO1B pathway as a possible HNSC diagnostic biomarker and therapeutic target.doi:10.1038/s41598-023-38847-7Li, ZehaoQiu, Xinguang