PTPRG‐AS1Background and Aim Esophageal squamous cell carcinoma (ESCC) is the most significant subtype of esophageal cancer featured with high occurrence. Long noncoding RNAs (lncRNAs) have been proved to modulate the biological properties of cancer cells, including cell proliferation, invasion, ...
qRT-PCR assay was performed to measure the expressions of PTPRG-AS1 and microRNA-185-5p (miR-185-5p). Cell viability, migration, invasion, and apoptosis were determined by CCK-8 assay, colony formation assay, transwell assay, and flow cytometry assay. Autophagy was evaluated using GFP-LC3 ...
NPC cell line CNE-2 was adopted for in vitro study and transfected with mimic or short hairpin RNA of miR-194-3p and PTPRG-AS1. The radioactive sensitivity, cell viability, migration, invasion, and apoptosis were detected. PTPRG-AS1 and PRC1 were upregulated in NPC, whereas miR-194-3p ...
Furthermore, the study of mechanism verified that PTPRG-AS1 could increase STAT3 expression through miR-665 to promote tumor progression of CRC. Conclusion In this study, PTPRG-AS1 maintains stemness features and promotes oxaliplatin resistance in CRC through modulating miR-665/STAT3.Fu, Chendong...
LncRNA PTPRG-AS1miR-5590-3p增殖迁移侵袭目的 探讨LncRNA PTPRG-AS1对乳腺癌细胞增殖,迁移和侵袭的影响及可能机制.方法 以正常乳腺上皮细胞MCF-10A为对照,qRT-PCR法检测乳腺癌细胞系(MCF-7,T47D和BT549)中LncRNA PTPRG-AS1和miR-5590-3p表达.分别转染si-LncRNA PTPRG-AS1,miR-5590-3p mimics,共转染si-...
lncRNA PTPRG-AS1细胞增殖凋亡目的:探究氟伐他汀钠对结直肠癌SW620细胞增殖,凋亡的影响及可能机制.方法:体外培养SW620细胞,正常结直肠上皮FHC细胞,qRT-PCR法检测细胞中lncRNA PTPRG-AS1表达.SW620细胞分为对照组,氟伐他汀钠-低,中,高组,si-PTPRG-AS1组,si-NC组,氟伐他汀钠+pcDNA-PTPRG-AS1组,氟伐他汀钠...
Retraction Note: Long non-coding RNA PTPRG-AS1 promotes cell tumorigenicity in epithelial ovarian cancer by decoying microRNA-545-3p and consequently enhancing HDAC4 expressionNON-coding RNALINCRNAOVARIAN epithelial cancerGENE expressionEPITHELIAL cells...
LncRNA PTPRG-AS1 maintains stem-cell-like features and promotes oxaliplatin resistance in colorectal cancer via regulating the miR-665 and STAT3 axisdoi:10.1007/s13273-022-00314-1Molecular & Cellular Toxicology - Colorectal cancer (CRC) is one of the most prevalent malignant cancers worldwide. ...
NPC cell line CNE‐2 was adopted for in vitro study and transfected with mimic or short hairpin RNA of miR‐194‐3p and PTPRG‐AS1. The radioactive sensitivity, cell viability, migration, invasion, and apoptosis were detected. PTPRG‐AS1 and PRC1 were upregulated in NPC, whereas miR‐194...