侵袭迁移PI3K/AKT背景长链非编码RNA(long non-coding RNA, lnc RNA)肿瘤蛋白翻译调节因子1-反义RNA1(tumor protein translationally controlled regulator 1-antisence RNA1,TPT1-AS1)TPT1-AS1可通过不同的作用方式影响肿瘤的侵袭转移,但其在肝癌中的具体作用和相关作用机制还有待进一步的实验验证.目的探讨lnc RNA ...
TPT1‐AS1Background Long non‐coding RNAs (lncRNAs) play crucial roles in cellular processes, with dysregulation implicated in various diseases, including cancers. The lncRNA TPT1‐AS1 (TPT1 Antisense RNA 1) promotes tumor progression in several cancers, including ovarian cancer (OC), but its ...
TPT1-AS1 overexpression and knockdown experiments revealed that TPT1-AS1 promoted cell colony formation, proliferation, migration, invasion and EMT progression of CC cells in vitro and in vivo. The underlying mechanism indicated that TPT1-AS1 functioned as an endogenous sponge for miR-324-5p in ...
TPT1-AS1翻译调节肿瘤蛋白TCTP胃上皮肠化生自噬目的:胃肠上皮化生(intestinal metaplasia,IM)作为胃癌重要的癌前病变,其发生发展是由多种因素共同作用的结果.本组前期研究表明,翻译调节肿瘤蛋白TCTP与肠化型萎缩性胃炎相关,可诱导肠化核心因子CDX2的表达.TPT1-AS1是位于TCTP反义链的长链非编码RNA,其与胃肠上皮化生的...
(N-cadherin)蛋白表达;Transwell检测细胞迁移;荧光素酶报告实验检测TPT1-AS1对miR-30c的靶向调控.结果肺癌组织中TPT1-AS1高表达(P<0.05).过表达TPT1-AS1或抑制miR-30c表达,G0期细胞所占比例显著降低,S期细胞所占比例显著升高(P<0.05),G2期细胞所占比例差异无统计学意义(P>0.05);细胞克隆形成数显著升高,迁移...
目的 分析长链非编码RNA(lncRNA)TPT1-AS1在非小细胞肺癌中的表达及其与临床病理特征的关系.方法 收集2014年7月至2016年9月陕西省核工业二一五医院非小细胞肺癌标本及癌旁组织各100例,采用实时荧光定量PCR(qRT-PCR)检测非小细胞肺癌标本,癌旁组织中lncRNA TPT1-AS1表达情况,分析lncRNA TPT1-AS1表达水平与非小...
目的:研究长链非编码RNA(LncRNA)肿瘤蛋白翻译调节因子1(TPT1)-反义RNA1(AS1)对前列腺癌细胞增殖,侵袭的影响.方法:体外培养人正常前列腺上皮细胞(RWPE-1)和前列腺癌细胞系雄激素非依赖f生前列腺癌(LNCa P),DU-145,PC-3,22RV1,实时荧光定量PCR(qRT-PCR)检测各细胞系中LncRNA TPT1-AS1表达水平;选取表达...
The long noncoding RNA (lncRNA) TPT1-AS1 has been reported to be involved in the development of multiple cancers. However, its clinical value, biological function, and underlying molecular mechanism in breast cancer (BC) remain unclear. In the present study, TPT1-AS1 expression was decreased ...
miR‐770‐5p, which directly targeted STMN1, could be downregulated by TPT1‐AS1. Subsequently, in glioma cells, TPT1‐AS1 can function to competitively bind to miR‐770‐5p, thus regulatEing STMN1 expression. Moreover, glioma cell proliferation and autophagy could be mediated through the TPT...
Furthermore, TPT1-AS1 was regarded as a promising biomarker for the diagnosis, prognosis and treatment of several human diseases. In this review, we summarize the role of TPT1-AS1 in human diseases with the aspects of its expression, relevant clinical characteristics, molecular mechanisms, ...