LncRNA TTN-AS1 is expected to become a new molecular site targeting breast cancer intervention.闫军周高晋马曙涛米尔夏提·米吉提帕合热迪尼马博Progress in Modern Biomedicine
在这项研究中,已经确定了长非编码RNA TTN-AS1(lncRNA-TTN-AS1),其以与人类titin(TTN)基因相反的方向转录,并在皮肤黑色素瘤(SKCM)中进行了探索。我们发现TTN和lncRNA-TTN-AS1的表达在SKCM细胞中具有显着正相关。在功能上,TTN和lncRNA-TTN-AS1的异位表达在体外和体内均促进SKCM的肿瘤发生和转移。而且,敲除...
Functionally, TTN-AS1 knockdown inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition in PTC, whereas overexpression of TTN-AS1 led to the opposite results. Mechanistically, TTN-AS1 acted as a competing endogenous RNA by sponging microRNA-153-3p (miR-153-3p) to ...
lncRNA TTN‑AS1 upregulates RUNX1 to enhance glioma progression via sponging miR‑27b‑3p Comments Keliang Chang,Genwei Wang,Jinfeng Lou,Sha Hao,Ranbo Lv,Desheng Duan,Wanhong Zhang,Yingchang Guo,Pengfei Wang #1Actinopolyspora biskrensiscomment accepted May 2024 The images in Figure 7E seem ...
Fig. 1: The expression of lncRNA TTN-AS1, miR-320a, and NRP-1 and their correlation in CCA tissues. The expression of TTN-AS1 (a), NRP-1 mRNA (b), and mature miR-320a (c) in 39 pairs of human CCA tissues and corresponding adjacent normal biliary tissues was detected by qRT-PCR...
Objective: To investigate the molecular mechanism of extracellular long chain non coding RNA (lncRNA) TTN-AS1 mediated miR-524-5p through transforming growth factor β(TGFβ/Smads signaling pathway, then to regulate the breast cancer progression. Firstly, real-time fluorescence quantitative polymerase ...
Figs 2E and 4E,F of "LncRNA TTN‑AS1 promotes endometrial cancer by sponging miR‑376a‑3p" (Shen et al 2020). Details of panels were extracted to become Figs 2E,F from "BRD4 promotes tumor progression and NF-κB/CCL2-dependent tumor-associated macrophage recruitment in GIST" (Mu ...
However, the function of LINC00680 and TTN-AS1 in the progression of glioblastomas is still elusive. In this study, we detected that LINC00680 and TTN-AS1 were upregulated in glioblastoma cells. RNA-binding protein EIF4A3 could prolong the half-life of LINC00680 and TTN-AS1. Knockdown of...
一、毛俊海担任职务:毛俊海目前担任大庆高新区飞驰减振器制造有限公司法定代表人,同时在4家企业担任高管,包括担任大庆高新区飞驰减振器制造有限公司董事长,洋浦景辉实业有限公司监事;二、毛俊海的商业合作伙伴:基于公开数据展示,毛俊海目前有10个商业合作伙伴,包括董凯、胡晓艳、张东志等。 财产...
长链非编码RNA TTN-AS1富集分析目的急性肾损伤(AKI)是严重肝病,尤其是终末期肝病的常见且病死率较高的并发症,其病因一般分为肾前性,肾性和肾后性损伤.由于不同类型的肾损伤需要采用不同的治疗方法,早期识别和鉴别诊断肾损伤尤为重要,早期确认AKI的亚型并进行疾病导向治疗有助于恢复.然而,目前仍然缺乏早期敏感且...