此前研究鉴定出TPP1 OB折叠结构域的N端区域(NOB)及其谷氨酸-亮氨酸富集区(TEL)对激活端粒酶活性并促进其招募十分关键。本结构显示,NOB和TEL与TERT共形成3段结合区域:NOB坐落于TEN结构域和IFD形成的疏水裂隙中;TEL中的谷氨酸富集区折叠成一个短的α-...
6. Blackburn, E.H. and K. Collins, Telomerase: an RNP enzyme synthesizes DNA.Cold Spring Harb Perspect Biol, 2011. 3(5). 7. Aramburu, T., S. Plucinsky, and E. Skordalakes, POT1-TPP1 telomere length regulation a...
今天给各位翻译的是2014年《JOURNAL OF BIOLOGICAL CHEMISTRY》期刊文章:The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7。 概要 背景:端粒蛋白TPP1的调节对端粒功能至关重要。 结果:TPP1是泛素化的,是去泛素化酶USP7的底物。 结论:TPP1泛素化不影响其已知的...
TPPII Enzyme Promotes Stimulation Of Fat CellsNews Staff
TRIPEPTIDYL PEPTIDASE I, TPP1, is a lysosomal exopeptidase that sequentially removes tripeptides from the N termini of proteins. The proenzyme has an apparent molecular mass of 66 kD, and the mature enzyme has an apparent molecular mass of 46 to 48 kD. Defects in TPP1 are the cause of ...
别名:焦磷酸硫胺素;氯化脱羧辅酶;TPPCAS号:154-87-0分子式:C12H19N4O7P2S·Cl分子量:460.77储存条件:2～8℃纯度:≥98%性状:白色或类白色结晶粉末相关搜索:辅羧酶(TPP),焦磷酸硫胺素,氯化脱羧辅酶,TPP,Cocarboxylase,154-87-0首页 | 关于我们 | 联系我们 | 在线咨询 | 网站地图 ...
Description :TPP1 is a member of the sedolisin family of serine proteases. The proenzyme is activated in thelysosome by auto-proteolysis where it cleaves tripeptides from the N-termini of substrates.Mutations of TPP1 are associated with late-infantile neuronal ceroid lipofuscinosis andSpinocerebellar...
TPP1 Polyclonal Antibody for WB, IHC, ELISA Host / Isotype Rabbit / IgG Reactivity human, mouse, rat Applications WB, IHC, ELISA Conjugate Unconjugated Publications 1 Review Product Cat no :12479-1-AP Synonyms CLN2, GIG1, LPIC, TPP 1, TPP I, TPP1, Tripeptidyl aminopeptidase, Tripeptidyl...
背景资料Tripeptidyl-peptidase 2 is an enzyme that in humans is encoded by the TPP2 gene.This gene encodes a mammalian peptidase that,at neutral pH,removes tripeptides from the N terminus of longer peptides.The protein has a specialized function that is essential for some MHC class I antigen...
A main-chain liquid-crystalline polyether has been synthesized from 1-(4-hydroxy-4'-biphenylyl)-2-(4-hydroxyphenyl)propane and 1,12-dibromododecane, TPP(n ... Rong-Ming,Ho,Yeocheol,... - 《Macromolecules》 被引量: 435发表: 1997年 A bifunctional TPS-TPP enzyme from yeast confers toleranc...